The purpose of this study was to describe the clinical and gross pathological findings, treatment, and outcome in three dogs receiving deracoxib that developed proximal duodenal perforation and subsequent septic peritonitis. Clinical findings were acute vomiting and anorexia following initiation of deracoxib therapy. Deracoxib dosages ranged from 2 to 3 mg/kg per os q 24 hours. In each dog, exploratory laparotomy revealed duodenal perforations approximately 1 cm orad to the major duodenal papilla. Two out of three dogs survived following exploratory laparotomy. Two of three dogs in the present case series received the approved deracoxib dosage. Dogs receiving deracoxib, even at labeled dosages, should be monitored judiciously for signs of gastrointestinal disease.
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July/August 2010
Case Reports|
July 01 2010
Proximal Duodenal Perforation in Three Dogs Following Deracoxib Administration
J. Brad Case, DVM, BS;
J. Brad Case, DVM, BS
Department of Surgery, Flatiron Veterinary Specialists, 230 South Main Street, Longmont, Colorado 80501
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Jennifer L. Fick, DVM, BS, Diplomate ACVS;
Jennifer L. Fick, DVM, BS, Diplomate ACVS
Department of Surgery, Flatiron Veterinary Specialists, 230 South Main Street, Longmont, Colorado 80501
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Matthew B. Rooney, DVM, MS, Diplomate ACVS
Matthew B. Rooney, DVM, MS, Diplomate ACVS
Department of Surgery, Flatiron Veterinary Specialists, 230 South Main Street, Longmont, Colorado 80501
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J Am Anim Hosp Assoc (2010) 46 (4): 255–258.
Citation
J. Brad Case, Jennifer L. Fick, Matthew B. Rooney; Proximal Duodenal Perforation in Three Dogs Following Deracoxib Administration. J Am Anim Hosp Assoc 1 July 2010; 46 (4): 255–258. doi: https://doi.org/10.5326/0460255
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