A third-generation fluoroquinolone, pradofloxacin (PRA), is currently being developed to treat bacterial infections in dogs. The purpose of this study was to assess the clinical efficacy in 20 dogs affected with superficial and deep pyoderma. An initial aerobic skin culture was performed in dogs with superficial pyoderma; aerobic/anaerobic tissue culture was performed in dogs with deep pyoderma; and skin cytology and biopsies were obtained from all dogs. Pradofloxacin (approximately 3 mg/kg per os [PO]) was administered daily to all dogs. Clinical efficacy was recorded at 4 weeks for dogs with superficial pyoderma and at 3 and 6 weeks for dogs with deep pyoderma. At a mean dosage of 3.7 mg/kg PO once daily, PRA treatment resulted in an excellent to good clinical response within 3 to 6 weeks for all 20 dogs with superficial and deep pyoderma.
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September/October 2010
Dermatology|
September 01 2010
Evaluation of the Clinical Efficacy of Pradofloxacin Tablets for the Treatment of Canine Pyoderma
Christina Restrepo, DVM;
Christina Restrepo, DVM
Dermatology Service (Restrepo, Spiegel), the Department of Medicine and Epidemiology (Ihrke, White), and the Department of Pathology (Affolter), School of Veterinary Medicine, University of California, Davis, California 95616-8747
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Peter J. Ihrke, VMD, Diplomate ACVD;
Peter J. Ihrke, VMD, Diplomate ACVD
Dermatology Service (Restrepo, Spiegel), the Department of Medicine and Epidemiology (Ihrke, White), and the Department of Pathology (Affolter), School of Veterinary Medicine, University of California, Davis, California 95616-8747
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Stephen D. White, DVM, Diplomate ACVD;
Stephen D. White, DVM, Diplomate ACVD
Dermatology Service (Restrepo, Spiegel), the Department of Medicine and Epidemiology (Ihrke, White), and the Department of Pathology (Affolter), School of Veterinary Medicine, University of California, Davis, California 95616-8747
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Ian B. Spiegel, Mhs VMD, Diplomate ACVD;
Ian B. Spiegel, Mhs VMD, Diplomate ACVD
Dermatology Service (Restrepo, Spiegel), the Department of Medicine and Epidemiology (Ihrke, White), and the Department of Pathology (Affolter), School of Veterinary Medicine, University of California, Davis, California 95616-8747
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Verena K. Affolter, Dr. Med. Vet., Diplomate ECVP, PhD
Verena K. Affolter, Dr. Med. Vet., Diplomate ECVP, PhD
Dermatology Service (Restrepo, Spiegel), the Department of Medicine and Epidemiology (Ihrke, White), and the Department of Pathology (Affolter), School of Veterinary Medicine, University of California, Davis, California 95616-8747
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J Am Anim Hosp Assoc (2010) 46 (5): 301–311.
Citation
Christina Restrepo, Peter J. Ihrke, Stephen D. White, Ian B. Spiegel, Verena K. Affolter; Evaluation of the Clinical Efficacy of Pradofloxacin Tablets for the Treatment of Canine Pyoderma. J Am Anim Hosp Assoc 1 September 2010; 46 (5): 301–311. doi: https://doi.org/10.5326/0460301
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