Canine leishmaniasis during pregnancy is rarely reported, even in countries where the infection in dogs is endemic. The authors report a case of a 4 yr old bitch with leishmaniasis treated with meglumine antimoniate during pregnancy. The pregnancy and delivery were normal and the bitch presented improvement of the infection during treatment. Three puppies died within 2 days of birth and tested negative via real-time PCR for L. infantum. The two surviving puppies were followed clinically, serologically, and by real-time PCR until 1 yr of age with no evidence of congenital leishmaniasis. L. infantum DNA was detected with real-time PCR analysis of uterine tissue from the bitch at the time of ovariohysterectomy. PCR analysis was performed after an ovariohysterectomy of the bitch that was performed two months after parturition. Meglumine antimoniate use in the pregnant bitch may have prevented vertical transmission of leishmaniasis.
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January/February 2011
Case Reports|
January 01 2011
First Report of the Use of Meglumine Antimoniate for Treatment of Canine Leishmaniasis in a Pregnant Dog
Eva Spada, DVM, PhD;
Department of Veterinary Clinical Science, Faculty of Veterinary Medicine, University of Milan, Italy (E.S., D.P., D.G., R.P., E.F.); and Department of Animal Pathology, Hygiene and Veterinary Public Health, Faculty of Veterinary Medicine, University of Milan, Italy (V.G.).
Correspondence: [email protected] (E.S.)
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Daniela Proverbio, DVM, PhD;
Daniela Proverbio, DVM, PhD
Department of Veterinary Clinical Science, Faculty of Veterinary Medicine, University of Milan, Italy (E.S., D.P., D.G., R.P., E.F.); and Department of Animal Pathology, Hygiene and Veterinary Public Health, Faculty of Veterinary Medicine, University of Milan, Italy (V.G.).
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Debora Groppetti, DVM, PhD;
Debora Groppetti, DVM, PhD
Department of Veterinary Clinical Science, Faculty of Veterinary Medicine, University of Milan, Italy (E.S., D.P., D.G., R.P., E.F.); and Department of Animal Pathology, Hygiene and Veterinary Public Health, Faculty of Veterinary Medicine, University of Milan, Italy (V.G.).
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Roberta Perego, DVM;
Roberta Perego, DVM
Department of Veterinary Clinical Science, Faculty of Veterinary Medicine, University of Milan, Italy (E.S., D.P., D.G., R.P., E.F.); and Department of Animal Pathology, Hygiene and Veterinary Public Health, Faculty of Veterinary Medicine, University of Milan, Italy (V.G.).
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Valeria Grieco, DVM, PhD;
Valeria Grieco, DVM, PhD
Department of Veterinary Clinical Science, Faculty of Veterinary Medicine, University of Milan, Italy (E.S., D.P., D.G., R.P., E.F.); and Department of Animal Pathology, Hygiene and Veterinary Public Health, Faculty of Veterinary Medicine, University of Milan, Italy (V.G.).
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Elisabetta Ferro, DVM
Elisabetta Ferro, DVM
Department of Veterinary Clinical Science, Faculty of Veterinary Medicine, University of Milan, Italy (E.S., D.P., D.G., R.P., E.F.); and Department of Animal Pathology, Hygiene and Veterinary Public Health, Faculty of Veterinary Medicine, University of Milan, Italy (V.G.).
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J Am Anim Hosp Assoc (2011) 47 (1): 67–71.
Citation
Eva Spada, Daniela Proverbio, Debora Groppetti, Roberta Perego, Valeria Grieco, Elisabetta Ferro; First Report of the Use of Meglumine Antimoniate for Treatment of Canine Leishmaniasis in a Pregnant Dog. J Am Anim Hosp Assoc 1 January 2011; 47 (1): 67–71. doi: https://doi.org/10.5326/JAAHA-MS-5508
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