A 7 mo old female English springer spaniel was presented with diarrhea, vomiting, apathy, and hyperthermia. Further examinations revealed generalized lymphadenomegaly consistent with sterile neutrophilic-macrophagic lymphadenitis and pulmonary involvement. Subcutaneous nodules developed one day after presentation. Histology was consistent with sterile idiopathic nodular panniculitis and vasculitis. No infectious organism was isolated. The dog responded to prednisolone, but relapsed during medication tapering. Cyclosporine had to be added to control the disease. No further relapse had occurred 98 wk after the first presentation. This is an unusual presentation of a systemic sterile neutrophilic-macrophagic lymphadenitis with nodular panniculitis and vasculitis associated with gastrointestinal and pulmonary signs.
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March/April 2011
Case Reports|
March 01 2011
Unusual Systemic Signs in a Dog with Sterile Neutrophilic-Macrophagic Lymphadenitis and Nodular Panniculitis
Julien R. S. Dandrieux, Dr.med.vet., DACVIM;
Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland (J.D., K.T., P.R., J.H., T.F.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (M.W.); and Clinic for Small Animal Surgery and Reproduction, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Munich, Germany (A.B.).
Correspondence: [email protected] (J.D.)
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Katrin Timm, Dr.med.vet.;
Katrin Timm, Dr.med.vet.
†
Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland (J.D., K.T., P.R., J.H., T.F.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (M.W.); and Clinic for Small Animal Surgery and Reproduction, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Munich, Germany (A.B.).
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Petra J. Roosje, DVM, PhD, DECVD;
Petra J. Roosje, DVM, PhD, DECVD
Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland (J.D., K.T., P.R., J.H., T.F.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (M.W.); and Clinic for Small Animal Surgery and Reproduction, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Munich, Germany (A.B.).
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Monika Welle, Dr.med.vet., PhD, DECVP;
Monika Welle, Dr.med.vet., PhD, DECVP
Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland (J.D., K.T., P.R., J.H., T.F.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (M.W.); and Clinic for Small Animal Surgery and Reproduction, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Munich, Germany (A.B.).
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Judith Howard, Dr.med.vet., DACVIM;
Judith Howard, Dr.med.vet., DACVIM
Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland (J.D., K.T., P.R., J.H., T.F.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (M.W.); and Clinic for Small Animal Surgery and Reproduction, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Munich, Germany (A.B.).
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Andreas Brühschwein, Dr.med.vet.;
Andreas Brühschwein, Dr.med.vet.
Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland (J.D., K.T., P.R., J.H., T.F.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (M.W.); and Clinic for Small Animal Surgery and Reproduction, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Munich, Germany (A.B.).
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Thierry Francey, Dr.med.vet., DACVIM
Thierry Francey, Dr.med.vet., DACVIM
Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland (J.D., K.T., P.R., J.H., T.F.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (M.W.); and Clinic for Small Animal Surgery and Reproduction, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Munich, Germany (A.B.).
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J Am Anim Hosp Assoc (2011) 47 (2): 117–121.
Citation
Julien R. S. Dandrieux, Katrin Timm, Petra J. Roosje, Monika Welle, Judith Howard, Andreas Brühschwein, Thierry Francey; Unusual Systemic Signs in a Dog with Sterile Neutrophilic-Macrophagic Lymphadenitis and Nodular Panniculitis. J Am Anim Hosp Assoc 1 March 2011; 47 (2): 117–121. doi: https://doi.org/10.5326/JAAHA-MS-5563
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