Two dogs presented with suspected renal disease and polycythemia. Abdominal ultrasound examinations performed on both dogs revealed coalescing masses causing bilateral renomegaly. Serum erythropoietin (EPO) concentrations were physiologically inappropriate. Postmortem examinations revealed renal T-cell lymphoma in both dogs. One of the two dogs also had involvement of the liver and mesentery. EPO-immunohistochemistry on tissue samples demonstrated positive staining in tumor cells and occasional normal renal cells. This report illustrates that paraneoplastic EPO production may induce polycythemia. The pattern of EPO-immunohistochemistry staining suggested that the mechanism of production was due to tumor production of EPO and local hypoxia-induced EPO production from compression of normal renal cells and vasculature.
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March/April 2011
Case Reports|
March 01 2011
Polycythemia and Inappropriate Erythropoietin Concentrations in Two Dogs with Renal T-cell Lymphoma
Alexandra S. Durno, MSc;
Alexandra S. Durno, MSc
Mississauga-Oakville Veterinary Emergency Hospital and Referral Group, Oakville, ON, Canada (A.D., J.W., M.G.); and Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada (D.B.).
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Jinelle A. Webb, DVM, MSc, DVSc, DACVIM;
Mississauga-Oakville Veterinary Emergency Hospital and Referral Group, Oakville, ON, Canada (A.D., J.W., M.G.); and Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada (D.B.).
Correspondence: [email protected] (J.W.)
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Meredith J. Gauthier, DVM, DACVIM (Oncology);
Meredith J. Gauthier, DVM, DACVIM (Oncology)
Mississauga-Oakville Veterinary Emergency Hospital and Referral Group, Oakville, ON, Canada (A.D., J.W., M.G.); and Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada (D.B.).
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Dorothee Bienzle, DVM, PhD, DACVP
Dorothee Bienzle, DVM, PhD, DACVP
Mississauga-Oakville Veterinary Emergency Hospital and Referral Group, Oakville, ON, Canada (A.D., J.W., M.G.); and Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada (D.B.).
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J Am Anim Hosp Assoc (2011) 47 (2): 122–128.
Citation
Alexandra S. Durno, Jinelle A. Webb, Meredith J. Gauthier, Dorothee Bienzle; Polycythemia and Inappropriate Erythropoietin Concentrations in Two Dogs with Renal T-cell Lymphoma. J Am Anim Hosp Assoc 1 March 2011; 47 (2): 122–128. doi: https://doi.org/10.5326/JAAHA-MS-5614
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