The objective of this article was to compare radiography, planar bone scintigraphy, and single-photon emission computed tomography (SPECT) to determine the size of osteosarcomas in long bones of dogs. Ten dogs with osteosarcoma in six radii, two humeri, one tibia, and one ulna were evaluated. Macroslides, mediolateral radiographs, planar scintigrams, and sagittal images from SPECT scans were used to obtain measurements. On the scintigraphic images, the edges of the tumor were established using the activity profile imaging tool. The radiographic magnification was factored. The mean percentage of tumor size overestimation was 9.29% on mediolateral radiographs, 5.35% on planar scintigrams, and 33.25% on SPECT images. The correlation coefficient adjusted for sample size was significantly higher (P<0.01) for technetium 99m (99mTc) hydroxyethylene diphosphonate (HDP) (75.5%) and radiography (61.3%) compared with indium 111–vitamin B12 (28.3%). The correlation coefficient for 99mTc–HDP was higher than that obtained for radiographs; however, statistical difference between the two variables was not demonstrated (P>0.05). 99mTc bone scan is a good estimator of intramedullary size of osteosarcoma in long bones when the activity profile tool to determine the margin of the tumor is used.
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July/August 2011
Original Studies|
July 01 2011
Radiography, 99mTc–HDP, and 111In Labeled Vitamin B12 SPECT of Canine Osteosarcoma: A Comparative Study
Robert Cruz, DVM, MSc, DACVR;
Department of Clinical Studies, University of Guelph, Guelph, ON Canada (R.C.); Veterinary Diagnostic Imaging Consultants, Fort Collins, CO (P.S.); Mayo Clinic, Rochester, Minnesota (D.C.); and Colorado State University, Fort Collins, CO (B.P., J.U.).
Correspondence: [email protected] (R.C.)
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Phillip Steyn, BVSc, MS, DACVR;
Phillip Steyn, BVSc, MS, DACVR
*
Department of Clinical Studies, University of Guelph, Guelph, ON Canada (R.C.); Veterinary Diagnostic Imaging Consultants, Fort Collins, CO (P.S.); Mayo Clinic, Rochester, Minnesota (D.C.); and Colorado State University, Fort Collins, CO (B.P., J.U.).
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Douglas Collins, MD;
Douglas Collins, MD
Department of Clinical Studies, University of Guelph, Guelph, ON Canada (R.C.); Veterinary Diagnostic Imaging Consultants, Fort Collins, CO (P.S.); Mayo Clinic, Rochester, Minnesota (D.C.); and Colorado State University, Fort Collins, CO (B.P., J.U.).
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Barbara Powers, DVM, MS, PhD, DACVP;
Barbara Powers, DVM, MS, PhD, DACVP
Department of Clinical Studies, University of Guelph, Guelph, ON Canada (R.C.); Veterinary Diagnostic Imaging Consultants, Fort Collins, CO (P.S.); Mayo Clinic, Rochester, Minnesota (D.C.); and Colorado State University, Fort Collins, CO (B.P., J.U.).
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John Urigh, RVT(CNMT)
John Urigh, RVT(CNMT)
Department of Clinical Studies, University of Guelph, Guelph, ON Canada (R.C.); Veterinary Diagnostic Imaging Consultants, Fort Collins, CO (P.S.); Mayo Clinic, Rochester, Minnesota (D.C.); and Colorado State University, Fort Collins, CO (B.P., J.U.).
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J Am Anim Hosp Assoc (2011) 47 (4): 229–235.
Citation
Robert Cruz, Phillip Steyn, Douglas Collins, Barbara Powers, John Urigh; Radiography, 99mTc–HDP, and 111In Labeled Vitamin B12 SPECT of Canine Osteosarcoma: A Comparative Study. J Am Anim Hosp Assoc 1 July 2011; 47 (4): 229–235. doi: https://doi.org/10.5326/JAAHA-MS-5600
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