A heart murmur was detected in a 10 mo old, female New Zealand White rabbit. Auscultation revealed cardiac murmurs both at the left and right hemithorax. Phonocardiography confirmed the systolic–diastolic nature of the left-sided and the systolic character of the right-sided murmur. Electrocardiography showed normal sinus rhythm; tall R waves and large T waves in lead II; and deep S waves in leads II, III, and aVF. Thoracic radiography demonstrated generalized cardiomegaly with prominent pulmonary vasculature. Echocardiography revealed a perimembraneous ventricular septal defect with aortic insufficiency. Signs of biventricular volume overload, relative pulmonic stenosis, and pulmonary valve insufficiency were also seen as consequences of the defect. Necropsy demonstrated a ventricular septal defect just below the aortic valve, a dilated pulmonary trunk, dilated and hypertrophied ventricles, dilated atria, and rightward displacement of the aortic root. Cardiac histopathology showed ventricular cardiomyocyte degeneration (swelling and hypereosinophilia of the cytoplasm with a loss of cross striation, and nuclear hyperchromasia), cartilaginous metaplasia of the aorta, and subendocardial fibrosis of the right ventricular flow tract.
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July/August 2011
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July 01 2011
Ventricular Septal Defect with Aortic Valve Insufficiency in a New Zealand White RabbitS
Károly Vörös, PhD, DSc;
Károly Vörös, PhD, DSc
*
Small Animal Clinic (K.V., S.H., A.M-L. N.vdH.) and Department of Pathology (F.S.), University of Veterinary Medicine Hanover, Hanover, Germany.
Correspondence: [email protected] (V.K.)
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Frauke Seehusen, DVM;
Frauke Seehusen, DVM
Small Animal Clinic (K.V., S.H., A.M-L. N.vdH.) and Department of Pathology (F.S.), University of Veterinary Medicine Hanover, Hanover, Germany.
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Stephan Hungerbühler, DVM;
Stephan Hungerbühler, DVM
Small Animal Clinic (K.V., S.H., A.M-L. N.vdH.) and Department of Pathology (F.S.), University of Veterinary Medicine Hanover, Hanover, Germany.
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Andrea Meyer-Lindenberg, DVM, PhD;
Andrea Meyer-Lindenberg, DVM, PhD
Small Animal Clinic (K.V., S.H., A.M-L. N.vdH.) and Department of Pathology (F.S.), University of Veterinary Medicine Hanover, Hanover, Germany.
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Nina von der Hoeh, DVM
Nina von der Hoeh, DVM
Small Animal Clinic (K.V., S.H., A.M-L. N.vdH.) and Department of Pathology (F.S.), University of Veterinary Medicine Hanover, Hanover, Germany.
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J Am Anim Hosp Assoc (2011) 47 (4): e42–e49.
Citation
Károly Vörös, Frauke Seehusen, Stephan Hungerbühler, Andrea Meyer-Lindenberg, Nina von der Hoeh; Ventricular Septal Defect with Aortic Valve Insufficiency in a New Zealand White Rabbit. J Am Anim Hosp Assoc 1 July 2011; 47 (4): e42–e49. doi: https://doi.org/10.5326/JAAHA-MS-5498
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