There is little information in veterinary literature regarding the diagnostic accuracy of aspirate cytology for the diagnosis of canine osteosarcoma (OSA). The authors compared the diagnostic accuracy of a novel method of cytologic collection, termed core aspirate cytology (CA), with fine needle aspiration (FNA) and histopathology in 27 dogs with lytic and/or proliferative bone lesions. Alkaline phosphatase (ALP) staining was performed to confirm the diagnosis of OSA cytologically. OSA was accurately diagnosed in 85% and 95% of FNA and CA, respectively. ALP staining was 100% sensitive for the diagnosis of OSA. CA using a bone marrow biopsy needle allowed for penetration of cortical bone and aspirate cytology with a larger bore needle than FNA; however, there was no significant difference in diagnostic accuracy between techniques. Aspirate cytology with ALP staining was a safe, accurate, and minimally invasive diagnostic test for the evaluation of suspected OSA lesions in dogs.
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September/October 2011
Original Studies|
September 01 2011
A Novel Method of Core Aspirate Cytology Compared to Fine-Needle Aspiration for Diagnosing Canine Osteosarcoma
Steven A. Neihaus, DVM;
Steven A. Neihaus, DVM
*
Affiliated Veterinary Specialists, Orange Park, FL (S.N., R.G.); Southeast Veterinary Oncology, Orange Park, FL (J.L.); Department of Veterinary Pathology, University of Illinois, College of Veterinary Medicine, Urbana, IL (A.B.); and Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC (L.B.).
Correspondence: [email protected] (S.N.)
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Jennifer E. Locke, DVM, DACVIM;
Jennifer E. Locke, DVM, DACVIM
Affiliated Veterinary Specialists, Orange Park, FL (S.N., R.G.); Southeast Veterinary Oncology, Orange Park, FL (J.L.); Department of Veterinary Pathology, University of Illinois, College of Veterinary Medicine, Urbana, IL (A.B.); and Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC (L.B.).
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Anne M. Barger, DVM, MS, DACVP;
Anne M. Barger, DVM, MS, DACVP
Affiliated Veterinary Specialists, Orange Park, FL (S.N., R.G.); Southeast Veterinary Oncology, Orange Park, FL (J.L.); Department of Veterinary Pathology, University of Illinois, College of Veterinary Medicine, Urbana, IL (A.B.); and Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC (L.B.).
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Luke B. Borst, DVM, PhD, DACVP;
Luke B. Borst, DVM, PhD, DACVP
Affiliated Veterinary Specialists, Orange Park, FL (S.N., R.G.); Southeast Veterinary Oncology, Orange Park, FL (J.L.); Department of Veterinary Pathology, University of Illinois, College of Veterinary Medicine, Urbana, IL (A.B.); and Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC (L.B.).
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Robert L. Goring, DVM, DACVS
Robert L. Goring, DVM, DACVS
Affiliated Veterinary Specialists, Orange Park, FL (S.N., R.G.); Southeast Veterinary Oncology, Orange Park, FL (J.L.); Department of Veterinary Pathology, University of Illinois, College of Veterinary Medicine, Urbana, IL (A.B.); and Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC (L.B.).
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J Am Anim Hosp Assoc (2011) 47 (5): 317–323.
Citation
Steven A. Neihaus, Jennifer E. Locke, Anne M. Barger, Luke B. Borst, Robert L. Goring; A Novel Method of Core Aspirate Cytology Compared to Fine-Needle Aspiration for Diagnosing Canine Osteosarcoma. J Am Anim Hosp Assoc 1 September 2011; 47 (5): 317–323. doi: https://doi.org/10.5326/JAAHA-MS-5676
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