This report describes the clinical, histopathologic, and imaging findings of multifocal oligodendrogliomas from three canine patients. Clinical history varied but included seizure activity and behavior changes. Neurologic examination abnormalities included ataxia, proprioceptive deficits, cranial nerve deficits, and changes in mentation. MRI in one patient revealed multifocal brain lesions; however, the MRI was normal in another one of the patients. Histopathologic evaluation identified multifocal neoplastic infiltrates in all three patients involving the cerebral cortex, brainstem, and spinal cord, with leptomeningeal extension in two of the three patients. All three patients were euthanized due to progression of their neurologic condition and/or complications due to aspiration pneumonia. Oligodendrogliomas should be considered a differential diagnosis for patients with multifocal brain disease.
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September/October 2011
Online-Only Articles|
September 01 2011
Multifocal Oligodendroglioma in Three Dogs
Michael W. Koch, VMD;
Department of Clinical Studies, Internal Medicine Section (M.K.), Neurology Section (S.L.), and Department of Pathobiology (M.S.), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
Correspondence: kochm@att.net (M.K.)
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Melissa D. Sánchez, VMD, PhD;
Melissa D. Sánchez, VMD, PhD
§
Department of Clinical Studies, Internal Medicine Section (M.K.), Neurology Section (S.L.), and Department of Pathobiology (M.S.), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
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Sam Long, BVSc, MVM, PhD, DECVN
Department of Clinical Studies, Internal Medicine Section (M.K.), Neurology Section (S.L.), and Department of Pathobiology (M.S.), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
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J Am Anim Hosp Assoc (2011) 47 (5): e77–e85.
Citation
Michael W. Koch, Melissa D. Sánchez, Sam Long; Multifocal Oligodendroglioma in Three Dogs. J Am Anim Hosp Assoc 1 September 2011; 47 (5): e77–e85. doi: https://doi.org/10.5326/JAAHA-MS-5551
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