A 4 yr old male castrated Labrador retriever was evaluated for a short history of inappetance, lethargy, small-bowel diarrhea, polyuria, and polydipsia. Clinicopathologic abnormalities were consistent with protein-losing nephropathy and renal azotemia. Expansive infectious disease testing implicated Babesia gibsoni via whole blood polymerase chain reaction. Renal histopathology results were consistent with membranoproliferative glomerulonephritis and immune complex deposition. The dog was treated with azithromycin, atovaquone, and one dose of corticosteroids/cyclophosphamide. Three months after therapy was completed, the dog was clinically healthy, and all clinicopathologic abnormalities (including Babesia species polymerase chain reaction) had resolved. Atypical presentations of Babesia gibsoni should be considered with proteinuric nephropathy.
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November/December 2011
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November 01 2011
Resolution of a Proteinuric Nephropathy Associated with Babesia gibsoni Infection in a Dog
Dennis J. Slade, DVM;
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA (D.S., L.K., M.L.); and Department of Small Animal Clinical Science (G.L.) and Department of Veterinary Pathobiology (B.B., F.C.), Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX.
Correspondence: [email protected] (D.S.).
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George E. Lees, DVM, MS, DACVIM;
George E. Lees, DVM, MS, DACVIM
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA (D.S., L.K., M.L.); and Department of Small Animal Clinical Science (G.L.) and Department of Veterinary Pathobiology (B.B., F.C.), Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX.
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Brian R. Berridge, DVM, PhD, DACVP;
Brian R. Berridge, DVM, PhD, DACVP
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA (D.S., L.K., M.L.); and Department of Small Animal Clinical Science (G.L.) and Department of Veterinary Pathobiology (B.B., F.C.), Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX.
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Fred J. Clubb, DVM, PhD, DACLAM;
Fred J. Clubb, DVM, PhD, DACLAM
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA (D.S., L.K., M.L.); and Department of Small Animal Clinical Science (G.L.) and Department of Veterinary Pathobiology (B.B., F.C.), Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX.
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Leslie A. Kuczynski, VMD;
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA (D.S., L.K., M.L.); and Department of Small Animal Clinical Science (G.L.) and Department of Veterinary Pathobiology (B.B., F.C.), Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX.
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Meryl P. Littman, VMD, DACVIM
Meryl P. Littman, VMD, DACVIM
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA (D.S., L.K., M.L.); and Department of Small Animal Clinical Science (G.L.) and Department of Veterinary Pathobiology (B.B., F.C.), Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX.
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J Am Anim Hosp Assoc (2011) 47 (6): e138–e144.
Citation
Dennis J. Slade, George E. Lees, Brian R. Berridge, Fred J. Clubb, Leslie A. Kuczynski, Meryl P. Littman; Resolution of a Proteinuric Nephropathy Associated with Babesia gibsoni Infection in a Dog. J Am Anim Hosp Assoc 1 November 2011; 47 (6): e138–e144. doi: https://doi.org/10.5326/JAAHA-MS-5576
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