A 3 yr old female spayed English setter mixed-breed dog presented with diarrhea, weight loss, side stepping to the right, and a right head tilt. Rectal and cerebrospinal fluid cytology and culture confirmed a diagnosis of Prototheca zopfii. MRI of the brain showed inflammation of the brain and meninges, ventriculomegaly, and syringomyelia. Treatment with prednisone, itraconazole, and amphotericin B lipid complex administered intrathecally yielded transient improvement. Progressive brainstem signs were noted, and a repeat MRI and cerebrospinal fluid analysis documented persistent disease. This is the first description of the MRI findings and treatment with intrathecal amphoteracin B lipid complex for protothecosis of the central nervous system. Protothecosis should be considered in dogs with chronic diarrhea and compatible MRI findings.
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March/April 2012
Case Reports|
March 01 2012
Serial MRI and CSF Analysis in a Dog Treated with Intrathecal Amphotericin B for Protothecosis
Martin Young, MS, DVM;
Bush Veterinary Neurology Service, Leesburg, VA (M.Y, W.B.); Department of Pathology, University of Pennsylvania, Philadelphia, PA (M.S.); M.R. Vets, Poderay, ID (P.G.); and Antech Diagnostic Laboratory, Mount Dora, FL (M.W.).
Correspondence: [email protected] (M.Y.)
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William Bush, VMD, DACVIM;
William Bush, VMD, DACVIM
Bush Veterinary Neurology Service, Leesburg, VA (M.Y, W.B.); Department of Pathology, University of Pennsylvania, Philadelphia, PA (M.S.); M.R. Vets, Poderay, ID (P.G.); and Antech Diagnostic Laboratory, Mount Dora, FL (M.W.).
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Melissa Sanchez, PhD, VMD;
Melissa Sanchez, PhD, VMD
Bush Veterinary Neurology Service, Leesburg, VA (M.Y, W.B.); Department of Pathology, University of Pennsylvania, Philadelphia, PA (M.S.); M.R. Vets, Poderay, ID (P.G.); and Antech Diagnostic Laboratory, Mount Dora, FL (M.W.).
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Pat Gavin, PhD, DVM, DACVR;
Pat Gavin, PhD, DVM, DACVR
Bush Veterinary Neurology Service, Leesburg, VA (M.Y, W.B.); Department of Pathology, University of Pennsylvania, Philadelphia, PA (M.S.); M.R. Vets, Poderay, ID (P.G.); and Antech Diagnostic Laboratory, Mount Dora, FL (M.W.).
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Mathew Williams, DVM, DACVP
Mathew Williams, DVM, DACVP
Bush Veterinary Neurology Service, Leesburg, VA (M.Y, W.B.); Department of Pathology, University of Pennsylvania, Philadelphia, PA (M.S.); M.R. Vets, Poderay, ID (P.G.); and Antech Diagnostic Laboratory, Mount Dora, FL (M.W.).
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J Am Anim Hosp Assoc (2012) 48 (2): 125–131.
Citation
Martin Young, William Bush, Melissa Sanchez, Pat Gavin, Mathew Williams; Serial MRI and CSF Analysis in a Dog Treated with Intrathecal Amphotericin B for Protothecosis. J Am Anim Hosp Assoc 1 March 2012; 48 (2): 125–131. doi: https://doi.org/10.5326/JAAHA-MS-5701
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