This report describes multiple endocrine neoplasia in a dog, which is a rare hereditary disorder characterized by the presence of two or more neoplasms of different endocrine tissues within a patient. A 14 yr old dog was evaluated for polyuria/polydipsia, polyphagia, and abdominal enlargement. Adrenal-dependent hyperadrenocorticism with concomitant left thyroid enlargement and a presumed abdominal metastatic lesion were diagnosed by an adrenocorticotropic hormone stimulation test, ultrasonography, and computed tomography. Trilostane therapy was initiated and resolved the clinical signs for 2 yr at which time the dog presented with left testicular enlargement. The dog was euthanized and was diagnosed with adrenocortical carcinoma, thyroid carcinoma, an abdominal mass compatible with a metastatic lymph node, and bilateral interstitial cell testicular adenomas. To the authors’ knowledge, this is the first report to describe the concomitant association of these types of endocrine neoplasms in a dog. The concomitant presence of these neoplasms could represent a potential variant of multiple endocrine neoplasia; however, the presence of the interstitial cell testicular adenomas may have only been an incidental finding. If any of these tumors are diagnosed, veterinarians should perform a thorough clinical assessment to evaluate for the presence of additional endocrine neoplasms or hyperplasia.
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March/April 2012
Case Reports|
March 01 2012
Potential Variant of Multiple Endocrine Neoplasia in a Dog
Daniela Proverbio, DVM, PhD;
Daniela Proverbio, DVM, PhD
Dipartimento di Scienze Cliniche Veterinarie (D.P., E.S., R.P., M.L., M.D.G., E.F.) and Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria (V.G.), Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
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Eva Spada, DVM, PhD;
Dipartimento di Scienze Cliniche Veterinarie (D.P., E.S., R.P., M.L., M.D.G., E.F.) and Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria (V.G.), Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
Correspondence: [email protected] (E.S.)
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Roberta Perego, DVM, PhD;
Roberta Perego, DVM, PhD
Dipartimento di Scienze Cliniche Veterinarie (D.P., E.S., R.P., M.L., M.D.G., E.F.) and Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria (V.G.), Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
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Valeria Grieco, DVM, PhD;
Valeria Grieco, DVM, PhD
Dipartimento di Scienze Cliniche Veterinarie (D.P., E.S., R.P., M.L., M.D.G., E.F.) and Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria (V.G.), Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
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Matteo Lodi, DVM, PhD;
Matteo Lodi, DVM, PhD
Dipartimento di Scienze Cliniche Veterinarie (D.P., E.S., R.P., M.L., M.D.G., E.F.) and Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria (V.G.), Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
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Mauro Di Giancamillo, DVM;
Mauro Di Giancamillo, DVM
Dipartimento di Scienze Cliniche Veterinarie (D.P., E.S., R.P., M.L., M.D.G., E.F.) and Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria (V.G.), Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
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Elisabetta Ferro, DVM
Elisabetta Ferro, DVM
Dipartimento di Scienze Cliniche Veterinarie (D.P., E.S., R.P., M.L., M.D.G., E.F.) and Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria (V.G.), Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
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J Am Anim Hosp Assoc (2012) 48 (2): 132–138.
Citation
Daniela Proverbio, Eva Spada, Roberta Perego, Valeria Grieco, Matteo Lodi, Mauro Di Giancamillo, Elisabetta Ferro; Potential Variant of Multiple Endocrine Neoplasia in a Dog. J Am Anim Hosp Assoc 1 March 2012; 48 (2): 132–138. doi: https://doi.org/10.5326/JAAHA-MS-5708
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