The dose-limiting toxicity of doxorubicin is cardiotoxicosis. The authors of this report hypothesized that by using their institution's adopted guidelines (that involve prescreening echocardiography and electrocardiography), they would detect pre-existing cardiac abnormalities that preclude doxorubicin administration in <10% of dogs. Of 101 dogs, only 6 were excluded from doxorubicin administration based on electrocardiogram abnormalities, with a majority of those arrhythmias classified as ventricular premature contractions. One patient was excluded based on echocardiogram alone due to hypertrophic cardiomyopathy. The incidence of cardiotoxicity in treated dogs was 8% (8/101). Additional pretreatment and ongoing studies are indicated to identify risk factors for cardiotoxicity.
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March/April 2012
Retrospective Studies|
March 01 2012
Value of Echocardiography and Electrocardiography as Screening Tools Prior to Doxorubicin Administration
William Ratterree, DVM;
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.
Correspondence: [email protected] (W.R.)
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Tracy Gieger, DVM, DACVIM, DACVR;
Tracy Gieger, DVM, DACVIM, DACVR
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.
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Romain Pariaut, DVM, DACVIM;
Romain Pariaut, DVM, DACVIM
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.
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Carley Saelinger, VMD;
Carley Saelinger, VMD
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.
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Keith Strickland, DVM, DACVIM
Keith Strickland, DVM, DACVIM
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.
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J Am Anim Hosp Assoc (2012) 48 (2): 89–96.
Citation
William Ratterree, Tracy Gieger, Romain Pariaut, Carley Saelinger, Keith Strickland; Value of Echocardiography and Electrocardiography as Screening Tools Prior to Doxorubicin Administration. J Am Anim Hosp Assoc 1 March 2012; 48 (2): 89–96. doi: https://doi.org/10.5326/JAAHA-MS-5680
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