The purpose of this study was to review the medical records of dogs that were either suspected or known to have ingested large doses of pimobendan and to describe the clinical signs associated with pimobendan toxicosis. The database of Pet Poison Helpline, an animal poison control center located in Minneapolis, MN, was searched for cases involving pimobendan toxicosis from Nov 2004 to Apr 2010. In total, 98 cases were identified. Of those, seven dogs that ingested between 2.6 mg/kg and 21.3 mg/kg were selected for further evaluation. Clinical signs consisted of cardiovascular abnormalities, including severe tachycardia (4/7), hypotension (2/7), and hypertension (2/7). In two dogs, no clinical signs were seen. Despite a wide safety profile, large overdoses of pimobendan may present risks for individual pets. Prompt decontamination, including emesis induction and the administration of activated charcoal, is advised in the asymptomatic patient. Symptomatic and supportive care should include the use of IV fluid therapy to treat hypotension and address hydration requirements and blood pressure and electrocardiogram monitoring with high-dose toxicosis. Practitioners should be aware of the clinical signs associated with high-dose pimobendan toxicosis. Of the dogs reported herein, all were hospitalized, responded to supportive care, and survived to discharge within 24 hr of exposure.
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July/August 2012
CASE SERIES|
July 01 2012
Clinical Signs of Cardiovascular Effects Secondary to Suspected Pimobendan Toxicosis in Five Dogs
L. Noelani Reinker, DVM;
L. Noelani Reinker, DVM
*
Metropolitan Veterinary Referral Services, Eden Prairie, MN (L.R.); Pet Poison Helpline, Minneapolis, MN (J.L., L.H); and Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY (M.R.).
Correspondence: [email protected] (L.R.)
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Justine A. Lee, DVM, DAVECC;
Justine A. Lee, DVM, DAVECC
Metropolitan Veterinary Referral Services, Eden Prairie, MN (L.R.); Pet Poison Helpline, Minneapolis, MN (J.L., L.H); and Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY (M.R.).
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Lynn R. Hovda, RPh, MS, DVM, DACVIM (Internal Medicine);
Lynn R. Hovda, RPh, MS, DVM, DACVIM (Internal Medicine)
Metropolitan Veterinary Referral Services, Eden Prairie, MN (L.R.); Pet Poison Helpline, Minneapolis, MN (J.L., L.H); and Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY (M.R.).
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Mark Rishniw, BVSc, PhD, DACVIM (Cardiology, Internal Medicine)
Mark Rishniw, BVSc, PhD, DACVIM (Cardiology, Internal Medicine)
Metropolitan Veterinary Referral Services, Eden Prairie, MN (L.R.); Pet Poison Helpline, Minneapolis, MN (J.L., L.H); and Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY (M.R.).
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J Am Anim Hosp Assoc (2012) 48 (4): 250–255.
Citation
L. Noelani Reinker, Justine A. Lee, Lynn R. Hovda, Mark Rishniw; Clinical Signs of Cardiovascular Effects Secondary to Suspected Pimobendan Toxicosis in Five Dogs. J Am Anim Hosp Assoc 1 July 2012; 48 (4): 250–255. doi: https://doi.org/10.5326/JAAHA-MS-5775
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