Treatment of dogs with acute canine polyradiculoneuritis (ACP) is restricted to physical rehabilitation and supportive care. In humans with Guillain-Barré syndrome, the counterpart of ACP, randomized trials show that IV immunoglobulin (IVIg) speeds recovery. The authors of the current study hypothesized that dogs with ACP would tolerate IVIg well and recover faster than dogs managed with supportive treatment only. Sixteen client-owned dogs with ACP were treated with IVIg, and 14 client-owned dogs served as a retrospective control group. Diagnosis was confirmed using clinical features, electrodiagnostics, cerebrospinal fluid analysis, and muscle/nerve biopsies. The duration of the initial progressive phase, the time from IVIg administration until the dogs were ambulating without assistance, and the duration of the complete episode were evaluated. Adverse reactions (anaphylaxis, mild hematuria) were observed in two dogs. Dogs treated with IVIg were ambulating without assistance after a median of 27.5 days (range, 15–127 days) from onset of clinical signs. The control group was ambulatory without assistance at a median of 75.5 days (range, 5–220 days). Even though this result is not statistically significant, there is a clear trend toward faster recovery in dogs treated with IVIg.
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September/October 2012
Original Studies|
September 01 2012
Clinical Course of Acute Canine Polyradiculoneuritis Following Treatment with Human IV Immunoglobulin
Katrin Hirschvogel, DVM;
Katrin Hirschvogel, DVM
Clinic of Small Animal Medicine, Ludwig-Maximilians University, Munich, Germany (K.H., L.M., A.F., T.S.); Tierklinik Haar, Haar, Germany (K.J.); Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany (K.M.); and Animal Health Trust, Lanwades Park, Kentford, Newmarket, England (E.B.).
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Konrad Jurina, DVM, Dr.med.vet., DECVN;
Konrad Jurina, DVM, Dr.med.vet., DECVN
Clinic of Small Animal Medicine, Ludwig-Maximilians University, Munich, Germany (K.H., L.M., A.F., T.S.); Tierklinik Haar, Haar, Germany (K.J.); Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany (K.M.); and Animal Health Trust, Lanwades Park, Kentford, Newmarket, England (E.B.).
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Tanja A. Steinberg, DVM, Dr.med.vet., DECVN;
Tanja A. Steinberg, DVM, Dr.med.vet., DECVN
Clinic of Small Animal Medicine, Ludwig-Maximilians University, Munich, Germany (K.H., L.M., A.F., T.S.); Tierklinik Haar, Haar, Germany (K.J.); Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany (K.M.); and Animal Health Trust, Lanwades Park, Kentford, Newmarket, England (E.B.).
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Lara A. Matiasek, DVM, Dr.med.vet., DECVN;
Lara A. Matiasek, DVM, Dr.med.vet., DECVN
Clinic of Small Animal Medicine, Ludwig-Maximilians University, Munich, Germany (K.H., L.M., A.F., T.S.); Tierklinik Haar, Haar, Germany (K.J.); Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany (K.M.); and Animal Health Trust, Lanwades Park, Kentford, Newmarket, England (E.B.).
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Kaspar Matiasek, DVM, Dr.med.vet., Dr.habil;
Kaspar Matiasek, DVM, Dr.med.vet., Dr.habil
Clinic of Small Animal Medicine, Ludwig-Maximilians University, Munich, Germany (K.H., L.M., A.F., T.S.); Tierklinik Haar, Haar, Germany (K.J.); Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany (K.M.); and Animal Health Trust, Lanwades Park, Kentford, Newmarket, England (E.B.).
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Elsa Beltrán, DVM, DECVN;
Elsa Beltrán, DVM, DECVN
Clinic of Small Animal Medicine, Ludwig-Maximilians University, Munich, Germany (K.H., L.M., A.F., T.S.); Tierklinik Haar, Haar, Germany (K.J.); Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany (K.M.); and Animal Health Trust, Lanwades Park, Kentford, Newmarket, England (E.B.).
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Andrea Fischer, DVM, Dr.med.vet., Dr.habil, DECVN, DACVIM (Neurology)
Clinic of Small Animal Medicine, Ludwig-Maximilians University, Munich, Germany (K.H., L.M., A.F., T.S.); Tierklinik Haar, Haar, Germany (K.J.); Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany (K.M.); and Animal Health Trust, Lanwades Park, Kentford, Newmarket, England (E.B.).
Correspondence: [email protected] (A.F.)
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J Am Anim Hosp Assoc (2012) 48 (5): 299–309.
Citation
Katrin Hirschvogel, Konrad Jurina, Tanja A. Steinberg, Lara A. Matiasek, Kaspar Matiasek, Elsa Beltrán, Andrea Fischer; Clinical Course of Acute Canine Polyradiculoneuritis Following Treatment with Human IV Immunoglobulin. J Am Anim Hosp Assoc 1 September 2012; 48 (5): 299–309. doi: https://doi.org/10.5326/JAAHA-MS-5651
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