One spayed female Labrador retriever and two castrated male golden retrievers were evaluated for chronic (i.e., ranging from 3 wk to 24 wk) neurologic signs localizable to the prosencephalon. Signs included seizures, circling, and behavior changes. MRI demonstrated extra-axial, contrast-enhancing, multiloculated, fluid-filled, cyst-like lesions with a mass effect, causing compression and displacement of brain parenchyma. Differential diagnoses included cystic neoplasm, abscess or other infectious cyst (e.g., alveolar hydatid cyst), or fluid-filled anomaly (e.g., arachnoid cyst). The cyst-like lesions were attached to the rostral falx cerebri in all cases. In addition, case 2 had a second polycystic mass at the caudal diencephalon. Surgical biopsy (case 3 with a single, rostral tumor via transfrontal craniectomy) and postmortem histology (in cases 1 and 2) confirmed polycystic meningiomas. Tumor types were transitional (cases 1 and 3) and fibrous (case 2), with positive immunohistochemical staining for vimentin. Case 3 was also positive for E-cadherin, s100, and CD34. In all cases, staining was predominantly negative for glial fibrillary acid protein and pancytokeratins, supporting a diagnosis of meningioma. This report describes the first cases of polycystic meningiomas in dogs. Polycystic meningiomas are a rare, but important, addition to the differential diagnoses for intracranial cyst-like lesions, significantly affecting planning for surgical resection and other therapeutic interventions.
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September/October 2012
Case Reports|
September 01 2012
Clinical and MRI Findings in Three Dogs with Polycystic Meningiomas
Fiona M. K. James, MSc, DVM, DVSc, DACVIM (Neurology);
Department of Clinical Studies (F.J., R.C., J.P.), Department of Pathobiology (A.P.), and Animal Health Laboratory (B.M.), Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN (A.F.); and Carolina Veterinary Specialists, Charlotte, NC (R.B.).
Correspondence: [email protected] (F.J.)
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Ronaldo C. da Costa, PhD, DVM, DACVIM (Neurology);
Ronaldo C. da Costa, PhD, DVM, DACVIM (Neurology)
*
Department of Clinical Studies (F.J., R.C., J.P.), Department of Pathobiology (A.P.), and Animal Health Laboratory (B.M.), Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN (A.F.); and Carolina Veterinary Specialists, Charlotte, NC (R.B.).
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Amy Fauber, MS, DVM, DACVS;
Amy Fauber, MS, DVM, DACVS
Department of Clinical Studies (F.J., R.C., J.P.), Department of Pathobiology (A.P.), and Animal Health Laboratory (B.M.), Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN (A.F.); and Carolina Veterinary Specialists, Charlotte, NC (R.B.).
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Andrew S. Peregrine, PhD, DVM, DEVPC;
Andrew S. Peregrine, PhD, DVM, DEVPC
Department of Clinical Studies (F.J., R.C., J.P.), Department of Pathobiology (A.P.), and Animal Health Laboratory (B.M.), Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN (A.F.); and Carolina Veterinary Specialists, Charlotte, NC (R.B.).
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Beverly McEwen, PhD, DVM, DACVP;
Beverly McEwen, PhD, DVM, DACVP
Department of Clinical Studies (F.J., R.C., J.P.), Department of Pathobiology (A.P.), and Animal Health Laboratory (B.M.), Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN (A.F.); and Carolina Veterinary Specialists, Charlotte, NC (R.B.).
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Joane M. Parent, DVM, MVetSc, DACVIM (Neurology);
Joane M. Parent, DVM, MVetSc, DACVIM (Neurology)
†
Department of Clinical Studies (F.J., R.C., J.P.), Department of Pathobiology (A.P.), and Animal Health Laboratory (B.M.), Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN (A.F.); and Carolina Veterinary Specialists, Charlotte, NC (R.B.).
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Robert Bergman, MS, DVM, DACVIM (Neurology)
Robert Bergman, MS, DVM, DACVIM (Neurology)
Department of Clinical Studies (F.J., R.C., J.P.), Department of Pathobiology (A.P.), and Animal Health Laboratory (B.M.), Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN (A.F.); and Carolina Veterinary Specialists, Charlotte, NC (R.B.).
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J Am Anim Hosp Assoc (2012) 48 (5): 331–338.
Citation
Fiona M. K. James, Ronaldo C. da Costa, Amy Fauber, Andrew S. Peregrine, Beverly McEwen, Joane M. Parent, Robert Bergman; Clinical and MRI Findings in Three Dogs with Polycystic Meningiomas. J Am Anim Hosp Assoc 1 September 2012; 48 (5): 331–338. doi: https://doi.org/10.5326/JAAHA-MS-5774
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