A 3.5 yr old Saint Bernard was evaluated for nonambulatory tetraparesis and cranial nerve dysfunction, and a 7 yr old rottweiler was evaluated for progressive paraparesis. Clinical signs of left-sided vestibular and general proprioceptive ataxia and cranial nerve VII dysfunction in the Saint Bernard suggested a lesion affecting the brain stem. Signs in the rottweiler consisted of general proprioceptive/upper motor neuron paraparesis, suggesting a lesion involving the third thoracic (T3) to third lumbar (L3) spinal cord segments. MRI was normal in the Saint Bernard, but an intra-axial lesion involving the T13–L2 spinal cord segments was observed in the rottweiler. In both dogs, the central nervous system (CNS) contained neoplastic cells with features consistent with gliomatosis cerebri (GC). In the Saint Bernard, neoplastic cells were present in the medulla oblongata and cranial cervical spinal cord. In the rottweiler, neoplastic cells were only present in the spinal cord. Immunohistochemistry disclosed two distinct patterns of CD18, nestin, and vimentin staining. GC is a rarely reported tumor of the CNS. Although GC typically involves the cerebrum, clinical signs in these two dogs reflected caudal brainstem and spinal cord involvement.
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September/October 2012
Case Reports|
September 01 2012
Gliomatosis Cerebri in Two Dogs
Brandon L. Plattner, PhD, DVM, DACVP;
Brandon L. Plattner, PhD, DVM, DACVP
*
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
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Marc Kent, DVM;
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
Correspondence: [email protected] (M.K.)
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Brian Summers, BVSc, PhD, MRCVS, FRCPath;
Brian Summers, BVSc, PhD, MRCVS, FRCPath
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
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Simon R. Platt, BVM&S, DECVN, DACVIM;
Simon R. Platt, BVM&S, DECVN, DACVIM
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
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A. Courtenay Freeman, DVM;
A. Courtenay Freeman, DVM
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
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Uriel Blas-Machado, PhD, DVM;
Uriel Blas-Machado, PhD, DVM
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
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Jessie Clemans, DVM;
Jessie Clemans, DVM
†
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
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Norman F. Cheville, PhD, DVM;
Norman F. Cheville, PhD, DVM
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
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David Garcia-Tapia, PhD, DVM
David Garcia-Tapia, PhD, DVM
§
Department of Veterinary Pathology (B.P., N.C., D. G-T.), Department of Veterinary Clinical Sciences (J.C.), College of Veterinary Medicine, Iowa State University, Ames, IA; Department of Small Animal Medicine and Surgery (M.K., S.P., A.F.), Diagnostic Laboratory (U.B-M.), College of Veterinary Medicine, University of Georgia, Athens, GA; and Pathology & Infectious Diseases, The Royal Veterinary College, Herts, United Kingdom (B.S.).
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J Am Anim Hosp Assoc (2012) 48 (5): 359–365.
Citation
Brandon L. Plattner, Marc Kent, Brian Summers, Simon R. Platt, A. Courtenay Freeman, Uriel Blas-Machado, Jessie Clemans, Norman F. Cheville, David Garcia-Tapia; Gliomatosis Cerebri in Two Dogs. J Am Anim Hosp Assoc 1 September 2012; 48 (5): 359–365. doi: https://doi.org/10.5326/JAAHA-MS-5796
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