Percent resistance and minimum inhibitory concentrations (MIC) were described for canine (n = 301) and feline (n = 75) pathogenic Escherichia coli (E. coli) isolates solicited during May 2005 to Sep 2005 from the Clinical Pharmacology Laboratory at Auburn University (n = 165) or commercial diagnostic laboratories ([CDL]; n = 211) from four regions in the USA. Drugs tested were amoxicillin (AMX), amoxicillin trihydrate/clavulanate potassium (AMXC), cefpodoxime (CFP), doxycycline (DXY), enrofloxacin (ENR), gentamicin (GM) and trimethoprim-sulfamethoxazole (TMS). Urinary isolates were most common (n = 174). Percent resistance was greatest for isolates from the respiratory tract, urine, and skin compared with the ear. Resistance was also greatest for samples sent from the south and central states compared with the western states (P ≤ 0.001). Percent resistance by drug was AMX (46 ± 2.6%) > AMXC (37 ± 2.5%) > CFP (21.8 ± 2%) = DXY (22 ± 2.1%) = ENR (20 ± 2.1%) = TMS (19 ± 2%) > GM (12 ± 1.7%). There was a significant difference in resistance between the different antibiotic drugs (P ≤ 0.001). Population MIC distributions were bimodal, and MICs were highest in samples from the southern states (P ≤ 0.001). E. coli resistance may limit its empirical treatment. For susceptible isolates, AMX and AMXC may be least effective and TMS most effective.
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November/December 2012
Original Studies|
November 01 2012
Antimicrobial Resistance and Pharmacodynamics of Canine and Feline Pathogenic E. coli in the United States
Dawn Boothe, PhD, DVM;
Department of Anatomy, Physiology and Pharmacology (D.B.), Department of Mathematics and Statistics (D.C.), and Department of Pathobiology (T.H.), Auburn University, Auburn, AL; Banfield The Pet Hospital, Columbia, SC (T.S.); and Division of Microbiology, USDA National Center for Toxicologic Research, Jefferson, AK (B.S.).
Correspondence: [email protected] (D.B.)
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Tim Smaha, DVM;
Tim Smaha, DVM
Department of Anatomy, Physiology and Pharmacology (D.B.), Department of Mathematics and Statistics (D.C.), and Department of Pathobiology (T.H.), Auburn University, Auburn, AL; Banfield The Pet Hospital, Columbia, SC (T.S.); and Division of Microbiology, USDA National Center for Toxicologic Research, Jefferson, AK (B.S.).
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D. Mark Carpenter, PhD;
D. Mark Carpenter, PhD
Department of Anatomy, Physiology and Pharmacology (D.B.), Department of Mathematics and Statistics (D.C.), and Department of Pathobiology (T.H.), Auburn University, Auburn, AL; Banfield The Pet Hospital, Columbia, SC (T.S.); and Division of Microbiology, USDA National Center for Toxicologic Research, Jefferson, AK (B.S.).
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Bashar Shaheen, PhD, DVM;
Bashar Shaheen, PhD, DVM
Department of Anatomy, Physiology and Pharmacology (D.B.), Department of Mathematics and Statistics (D.C.), and Department of Pathobiology (T.H.), Auburn University, Auburn, AL; Banfield The Pet Hospital, Columbia, SC (T.S.); and Division of Microbiology, USDA National Center for Toxicologic Research, Jefferson, AK (B.S.).
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Terri Hatchcock, MS
Terri Hatchcock, MS
Department of Anatomy, Physiology and Pharmacology (D.B.), Department of Mathematics and Statistics (D.C.), and Department of Pathobiology (T.H.), Auburn University, Auburn, AL; Banfield The Pet Hospital, Columbia, SC (T.S.); and Division of Microbiology, USDA National Center for Toxicologic Research, Jefferson, AK (B.S.).
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J Am Anim Hosp Assoc (2012) 48 (6): 379–389.
Citation
Dawn Boothe, Tim Smaha, D. Mark Carpenter, Bashar Shaheen, Terri Hatchcock; Antimicrobial Resistance and Pharmacodynamics of Canine and Feline Pathogenic E. coli in the United States. J Am Anim Hosp Assoc 1 November 2012; 48 (6): 379–389. doi: https://doi.org/10.5326/JAAHA-MS-5805
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