Feline colonic adenocarcinoma is a locally invasive, highly metastatic tumor that is most often treated with wide surgical excision (subtotal colectomy) and systemic chemotherapy either with or without nonsteroidal anti-inflammatory medications. In this retrospective study, the outcome of subtotal colectomy and adjuvant carboplatin in 18 client-owned cats is described. The median carboplatin dose was 200 mg/m2 (range, 200–254 mg/m2) q 4 wk with a median of five doses/cat (range was two to seven doses/cat). Limited toxicities were noted. Positive prognostic factors for the disease-free interval included cats that had weight loss as a presenting sign (P < 0.036) and negative prognostic factors for median survival included nodal and distant metastasis (178 versus 328 days and 200 versus 340 days, respectively). The median disease-free interval was 251 days (range, 37–528 days) and the median survival time was 269 days (range, 40–533 days). Subtotal colectomy and adjuvant carboplatin is a safe and potentially effective treatment for cats with colonic adenocarcinoma.
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November/December 2012
Retrospective Studies|
November 01 2012
A Review of 18 Cases of Feline Colonic Adenocarcinoma Treated with Subtotal Colectomies and Adjuvant Carboplatin
Theresa A. Arteaga, DVM, DACVIM (Oncology);
Pacific Veterinary Specialists, Monterey, CA (T.A.); Fifth Avenue Veterinary Specialists, New York, NY (J.M.); and Brightheart Veterinary Centers, Bedford Hills, NY (P.B.).
Correspondence: [email protected] (T.A.)
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JoAnne McKnight, DVM, DACVIM (Oncology);
JoAnne McKnight, DVM, DACVIM (Oncology)
Pacific Veterinary Specialists, Monterey, CA (T.A.); Fifth Avenue Veterinary Specialists, New York, NY (J.M.); and Brightheart Veterinary Centers, Bedford Hills, NY (P.B.).
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Philip J. Bergman, MS, DVM, DACVIM (Oncology), PhD
Philip J. Bergman, MS, DVM, DACVIM (Oncology), PhD
Pacific Veterinary Specialists, Monterey, CA (T.A.); Fifth Avenue Veterinary Specialists, New York, NY (J.M.); and Brightheart Veterinary Centers, Bedford Hills, NY (P.B.).
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J Am Anim Hosp Assoc (2012) 48 (6): 399–404.
Citation
Theresa A. Arteaga, JoAnne McKnight, Philip J. Bergman; A Review of 18 Cases of Feline Colonic Adenocarcinoma Treated with Subtotal Colectomies and Adjuvant Carboplatin. J Am Anim Hosp Assoc 1 November 2012; 48 (6): 399–404. doi: https://doi.org/10.5326/JAAHA-MS-5807
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