Three dogs were examined for clinical signs ultimately attributed to systemic fungal infections. One dog was evaluated for chronic, ulcerated dermal lesions and lymphadenomegaly; one dog was examined for acute onset of unilateral blepharospasm; and one dog had diarrhea and hematochezia. Two of the dogs were diagnosed with blastomycosis (one with disseminated disease and the other with the disease localized to the left eye). The third dog was diagnosed with disseminated histoplasmosis. None of the dogs originated from, or had traveled to, typical regions endemic for these fungal diseases. All diagnoses were established from histopathology and either polymerase chain reaction (PCR) or cytology and culture. The two dogs diagnosed with blastomycosis were treated with either itraconazole or ketoconazole with apparent resolution of the infections. The dog with ocular involvement had an enucleation prior to beginning therapy. The dog diagnosed with histoplasmosis was euthanized without treatment. In patients with characteristic clinical features, systemic fungal infections should still be considered as differential diagnoses regardless of their travel history.
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November/December 2012
Case Reports|
November 01 2012
Systemic Mycosis in Three Dogs from Nonendemic Regions
Carmela L. Pratt, DVM;
Department of Veterinary Clinical Sciences (C.P., R.S., E.S.) and Washington Animal Disease Diagnostic Laboratory (D.R.), Washington State University, Pullman, WA; and Cascade Veterinary Clinic, Inc., Wenatchee, WA (T.J.).
Correspondence: [email protected] (C.P.)
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Rance K. Sellon, DVM, PhD, DACVIM;
Rance K. Sellon, DVM, PhD, DACVIM
Department of Veterinary Clinical Sciences (C.P., R.S., E.S.) and Washington Animal Disease Diagnostic Laboratory (D.R.), Washington State University, Pullman, WA; and Cascade Veterinary Clinic, Inc., Wenatchee, WA (T.J.).
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Erick S. Spencer, MS, DVM, DACVIM;
Erick S. Spencer, MS, DVM, DACVIM
Department of Veterinary Clinical Sciences (C.P., R.S., E.S.) and Washington Animal Disease Diagnostic Laboratory (D.R.), Washington State University, Pullman, WA; and Cascade Veterinary Clinic, Inc., Wenatchee, WA (T.J.).
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Ty W. Johnson, DVM;
Ty W. Johnson, DVM
Department of Veterinary Clinical Sciences (C.P., R.S., E.S.) and Washington Animal Disease Diagnostic Laboratory (D.R.), Washington State University, Pullman, WA; and Cascade Veterinary Clinic, Inc., Wenatchee, WA (T.J.).
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Daniel J. Righter, DVM
Daniel J. Righter, DVM
Department of Veterinary Clinical Sciences (C.P., R.S., E.S.) and Washington Animal Disease Diagnostic Laboratory (D.R.), Washington State University, Pullman, WA; and Cascade Veterinary Clinic, Inc., Wenatchee, WA (T.J.).
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J Am Anim Hosp Assoc (2012) 48 (6): 411–416.
Citation
Carmela L. Pratt, Rance K. Sellon, Erick S. Spencer, Ty W. Johnson, Daniel J. Righter; Systemic Mycosis in Three Dogs from Nonendemic Regions. J Am Anim Hosp Assoc 1 November 2012; 48 (6): 411–416. doi: https://doi.org/10.5326/JAAHA-MS-5799
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