A 10 yr old bichon frise presented with a 3 mo history of polyuria, polydipsia, and hind limb weakness. Serum biochemistry revealed persistent hypokalemia. A left adrenal gland mass with right adrenal atrophy was detected ultrasonographically. Basal serum cortisol concentration was at the low end of normal (30 nmol/L; reference range, 30–140 nmol/L) and adrenocorticotropic hormone (ACTH)-stimulated cortisol concentration was low (199 nmol/L; reference range, 220–470 nmol/L). Basal serum 17-α-OH progesterone concentration was also low (0.03 ng/mL; reference range, 0.06–0.30 ng/mL), but the aldosterone concentration 2 hr after the ACTH stimulation was elevated (> 3,000 pmol/L; reference range, 197–2,103 pmol/L). A left adrenalectomy and nephrectomy were performed. Histopathology revealed an adrenocortical zona glomerulosa carcinoma. Surgical excision was considered incomplete; however, clinical signs resolved. Two years later, basal and ACTH-stimulated aldosterone concentrations were elevated. Computed tomography demonstrated a mass effect in the liver. The left lateral and left medial hepatic lobes were removed. Histopathology confirmed metastatic endocrine carcinoma. The patient was stable 1,353 days postsurgically (when this report was prepared). This is the first case report of a metastatic adrenal carcinoma that was successfully managed surgically for > 3 yr.
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November/December 2012
Case Reports|
November 01 2012
Adrenocortical Carcinoma in a Dog with Incomplete Excision Managed Long-term with Metastasectomy Alone
Jennifer L. Frankot, DVM;
Jennifer L. Frankot, DVM
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (J.F., E.B.); Veterinary Surgical Specialists of Orange County, Tustin, CA (P.S.); and Veterinary Diagnostic Laboratory, Colorado State University, Fort Collins, CO (B.P.).
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Ellen N. Behrend, PhD, VMD, DACVIM;
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (J.F., E.B.); Veterinary Surgical Specialists of Orange County, Tustin, CA (P.S.); and Veterinary Diagnostic Laboratory, Colorado State University, Fort Collins, CO (B.P.).
Correspondence: [email protected] (E.B.)
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Peter Sebestyen, DVM, DACVS;
Peter Sebestyen, DVM, DACVS
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (J.F., E.B.); Veterinary Surgical Specialists of Orange County, Tustin, CA (P.S.); and Veterinary Diagnostic Laboratory, Colorado State University, Fort Collins, CO (B.P.).
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Barbara E. Powers, PhD, DVM, DACVP
Barbara E. Powers, PhD, DVM, DACVP
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (J.F., E.B.); Veterinary Surgical Specialists of Orange County, Tustin, CA (P.S.); and Veterinary Diagnostic Laboratory, Colorado State University, Fort Collins, CO (B.P.).
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J Am Anim Hosp Assoc (2012) 48 (6): 417–423.
Citation
Jennifer L. Frankot, Ellen N. Behrend, Peter Sebestyen, Barbara E. Powers; Adrenocortical Carcinoma in a Dog with Incomplete Excision Managed Long-term with Metastasectomy Alone. J Am Anim Hosp Assoc 1 November 2012; 48 (6): 417–423. doi: https://doi.org/10.5326/JAAHA-MS-5800
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