A 4 yr old spayed female Labrador retriever was examined 4 hr after ingesting an overdose of phenylpropanolamine (PPA). Clinical signs included anxiety, piloerection, mucosal ulceration, cardiac arrhythmia, mydriasis, and hyphema. Clinicopathologic abnormalities included elevated creatine kinase (CK) and aspartate aminotransferase (AST), proteinuria, and pigmenturia. Ventricular tachycardia and severe systemic hypertension were documented. Hyphema and retinal detachment were documented oculus uterque (OU). Phenoxybenzamine, sotalol, and esmolol resolved the ventricular tachycardia, and blood pressure was controlled with nitroprusside. All clinicopathologic and cardiac abnormalities resolved within 7 days, and ocular changes resolved within 1 mo. Monitoring of blood pressure and rapid pharmacologic intervention were successful in controlling hypertension secondary to PPA overdose and minimizing retinal damage.
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January/February 2013
Case Reports|
January 01 2013
Systemic Hypertension and Hypertensive Retinopathy Following PPA Overdose in a Dog
Jennifer A. Ginn, DVM, DACVIM (Internal Medicine);
Jennifer A. Ginn, DVM, DACVIM (Internal Medicine)
*
Department of Medical Sciences (J.G., R.S.) and Department of Surgical Sciences (E.B.), University of Wisconsin School of Veterinary Medicine, Madison, WI.
Correspondence: [email protected] (J.G.)
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Ellison Bentley, DVM, DACVO;
Ellison Bentley, DVM, DACVO
Department of Medical Sciences (J.G., R.S.) and Department of Surgical Sciences (E.B.), University of Wisconsin School of Veterinary Medicine, Madison, WI.
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Rebecca L. Stepien, MS, DVM, DACVIM (Cardiology)
Rebecca L. Stepien, MS, DVM, DACVIM (Cardiology)
Department of Medical Sciences (J.G., R.S.) and Department of Surgical Sciences (E.B.), University of Wisconsin School of Veterinary Medicine, Madison, WI.
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J Am Anim Hosp Assoc (2013) 49 (1): 46–53.
Citation
Jennifer A. Ginn, Ellison Bentley, Rebecca L. Stepien; Systemic Hypertension and Hypertensive Retinopathy Following PPA Overdose in a Dog. J Am Anim Hosp Assoc 1 January 2013; 49 (1): 46–53. doi: https://doi.org/10.5326/JAAHA-MS-5692
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