A retrospective study was performed using 53 client owned dogs with leishmaniasis to determine whether the degree of proteinuria, evaluated by the urine protein/creatinine ratio (UP/C), changes following treatment with meglumine antimoniate and allopurinol. Medical records of dogs with leishmaniasis in clinical stage C (according to the Canine Leishmaniasis Working Group staging system) and either proteinuric or borderline proteinuric (according to the International Renal Interest Society [IRIS] staging system) were reviewed. All dogs were treated with meglumine antimoniate and allopurinol for 4–8 wk. After treatment, UP/C, total protein, and total globulin significantly decreased and albumin and the albumin/globulin ratio (A/G) increased. After treatment, 7 of the 53 dogs (13.4%) became nonproteinuric following either a proteinuric or borderline proteinuric stage. Moreover, 12 of the 53 proteinuric dogs (22.6%) changed their stage to borderline proteinuric. The antileishmaniasis treatment with meglumine antimoniate in combination with allopurinol in dogs significantly reduced the degree of proteinuria in a short period of time. The results of the current study may be useful to the veterinary practitioner in the clinical management of canine leishmaniasis (CanL) in dogs with proteinuric chronic kidney disease.
Skip Nav Destination
Article navigation
July/August 2013
Retrospective Studies|
July 01 2013
Variation of Proteinuria in Dogs with Leishmaniasis Treated with Meglumine Antimoniate and Allopurinol: A Retrospective Study
Marco Pierantozzi, PhD, DVM;
Marco Pierantozzi, PhD, DVM
*
Clinica Veterinaria Pirani, Reggio Emilia, Italy (M. Pierantozzi, A.Z.); Hospital Clínic Veterinari of the Universitat Autònoma de Barcelona, Spain (X.R.); Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Italy (S.P.); and Centro Veterinario Imperiese, Imperia, Italy (M. Poggi).
Correspondence: [email protected] (M.P.)
Search for other works by this author on:
Xavier Roura, PhD, DVM, DECVIM-CA;
Xavier Roura, PhD, DVM, DECVIM-CA
Clinica Veterinaria Pirani, Reggio Emilia, Italy (M. Pierantozzi, A.Z.); Hospital Clínic Veterinari of the Universitat Autònoma de Barcelona, Spain (X.R.); Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Italy (S.P.); and Centro Veterinario Imperiese, Imperia, Italy (M. Poggi).
Search for other works by this author on:
Saverio Paltrinieri, PhD, DVM, DECVCP;
Saverio Paltrinieri, PhD, DVM, DECVCP
Clinica Veterinaria Pirani, Reggio Emilia, Italy (M. Pierantozzi, A.Z.); Hospital Clínic Veterinari of the Universitat Autònoma de Barcelona, Spain (X.R.); Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Italy (S.P.); and Centro Veterinario Imperiese, Imperia, Italy (M. Poggi).
Search for other works by this author on:
Marco Poggi, DVM;
Marco Poggi, DVM
Clinica Veterinaria Pirani, Reggio Emilia, Italy (M. Pierantozzi, A.Z.); Hospital Clínic Veterinari of the Universitat Autònoma de Barcelona, Spain (X.R.); Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Italy (S.P.); and Centro Veterinario Imperiese, Imperia, Italy (M. Poggi).
Search for other works by this author on:
Andrea Zatelli, DVM
Andrea Zatelli, DVM
†
Clinica Veterinaria Pirani, Reggio Emilia, Italy (M. Pierantozzi, A.Z.); Hospital Clínic Veterinari of the Universitat Autònoma de Barcelona, Spain (X.R.); Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Italy (S.P.); and Centro Veterinario Imperiese, Imperia, Italy (M. Poggi).
Search for other works by this author on:
J Am Anim Hosp Assoc (2013) 49 (4): 231–236.
Citation
Marco Pierantozzi, Xavier Roura, Saverio Paltrinieri, Marco Poggi, Andrea Zatelli; Variation of Proteinuria in Dogs with Leishmaniasis Treated with Meglumine Antimoniate and Allopurinol: A Retrospective Study. J Am Anim Hosp Assoc 1 July 2013; 49 (4): 231–236. doi: https://doi.org/10.5326/JAAHA-MS-5840
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Long-Term Survival of Primary Intracranial Histiocytic Sarcoma Through Surgical Resection and Low-Dose CCNU
Kyosuke Hidari, DVM, Yuya Nakamoto, DVM, PhD, James K. Chambers, DVM, PhD, Kazuyuki Uchida, DVM, PhD, Isao Mori, DVM, Miwa Nakamoto, DVM
Microfilaria in the Urine of a Dog with Concurrent Urinary Bladder Sarcoma
Nicole Schlette, DVM, Erin Burton, DVM, MS, DACVP, Amber Harris, DVM, DACVIM (Internal Medicine), Kendall Langsten, DVM, DACVP, Erik Olson, DVM, PhD, DACVP, Daniel Heinrich, DVM, DACVP
Chronic Myelomonocytic Leukemia with Central Nervous System Involvement in a Dog
Ilaria Tartari, DVM, Fabio Tocco, DVM, Giorgio Cancedda, DVM, Veronica Angioni, DVM, Marco Podda, DVM, Antonella Gallucci, DVM, PhD, DECVN, EBVS
Treatment Outcomes of Canine Orbital Meningiomas in Seven Cases
Akihiro Uno, DVM, Ryota Iwasaki, DVM, PhD, Takashi Mori, DVM, PhD
Transient Hypoadrenocorticism in a 7-Week-Old Kitten
Alba Planas Vintro, BVM, Linda G. Martin, DVM, MS, DACVECC, Cassidy L. Cordon, DVM, Sabrina N. Hoehne, Dr. med. vet., DACVECC, DECVECC, Elizabeth B. Davidow, DVM, DACVECC