Data from 37 dogs with nasal carcinomas treated with two or more coarsely fractionated courses of radiation therapy (RT) were retrospectively reviewed. The median radiation dose for the first course of RT was 24 Gray (Gy). All dogs clinically responded, and 11 had complete resolution of signs for a median of 114 days. Dogs were retreated at relapse, with a median dose of 20 Gy, and 26 of 37 dogs (70%) had clinical responses. The second course of RT was initiated at a median of 150 days following completion of the first course. Side effects were mild: four dogs had chronic ocular conditions necessitating medication, one of which required enucleation. Median survival time (ST) from the first dose of RT was 453 days and 180 days from the first dose of the second course of RT. The following factors were examined but were not significant for survival: total RT dose, dose of the first course of RT, complete resolution of clinical signs, use of either chemotherapy or nonsteroidal anti-inflammatory drugs (NSAIDs), and stage (T1/T2 versus T3/T4). Dogs responded well to reirradiation with a subset experiencing chronic ocular side effects.
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September/October 2013
Retrospective Studies|
September 01 2013
Reirradiation of Canine Nasal Carcinomas Treated with Coarsely Fractionated Radiation Protocols: 37 Cases
Tracy Gieger, DVM;
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA (T.G., K.S.); New England Veterinary Oncology Group, Waltham, MA (S.S., K.R.); Georgia Veterinary Specialists, Sandy Springs, GA (D.J.); MedVet Medical and Cancer Centers for Pets, Worthington, OH (K.W.); and SAGE Veterinary Center, Campbell, CA (M.K.).
Correspondence: [email protected] (T.G.)
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Sheri Siegel, DVM;
Sheri Siegel, DVM
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA (T.G., K.S.); New England Veterinary Oncology Group, Waltham, MA (S.S., K.R.); Georgia Veterinary Specialists, Sandy Springs, GA (D.J.); MedVet Medical and Cancer Centers for Pets, Worthington, OH (K.W.); and SAGE Veterinary Center, Campbell, CA (M.K.).
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Kari Rosen, DVM;
Kari Rosen, DVM
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA (T.G., K.S.); New England Veterinary Oncology Group, Waltham, MA (S.S., K.R.); Georgia Veterinary Specialists, Sandy Springs, GA (D.J.); MedVet Medical and Cancer Centers for Pets, Worthington, OH (K.W.); and SAGE Veterinary Center, Campbell, CA (M.K.).
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Dorothy Jackson, DVM;
Dorothy Jackson, DVM
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA (T.G., K.S.); New England Veterinary Oncology Group, Waltham, MA (S.S., K.R.); Georgia Veterinary Specialists, Sandy Springs, GA (D.J.); MedVet Medical and Cancer Centers for Pets, Worthington, OH (K.W.); and SAGE Veterinary Center, Campbell, CA (M.K.).
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Kevin Ware, DVM;
Kevin Ware, DVM
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA (T.G., K.S.); New England Veterinary Oncology Group, Waltham, MA (S.S., K.R.); Georgia Veterinary Specialists, Sandy Springs, GA (D.J.); MedVet Medical and Cancer Centers for Pets, Worthington, OH (K.W.); and SAGE Veterinary Center, Campbell, CA (M.K.).
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Michael Kiselow, DVM;
Michael Kiselow, DVM
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA (T.G., K.S.); New England Veterinary Oncology Group, Waltham, MA (S.S., K.R.); Georgia Veterinary Specialists, Sandy Springs, GA (D.J.); MedVet Medical and Cancer Centers for Pets, Worthington, OH (K.W.); and SAGE Veterinary Center, Campbell, CA (M.K.).
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Keijiro Shiomitsu, DVM
Keijiro Shiomitsu, DVM
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA (T.G., K.S.); New England Veterinary Oncology Group, Waltham, MA (S.S., K.R.); Georgia Veterinary Specialists, Sandy Springs, GA (D.J.); MedVet Medical and Cancer Centers for Pets, Worthington, OH (K.W.); and SAGE Veterinary Center, Campbell, CA (M.K.).
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J Am Anim Hosp Assoc (2013) 49 (5): 318–324.
Citation
Tracy Gieger, Sheri Siegel, Kari Rosen, Dorothy Jackson, Kevin Ware, Michael Kiselow, Keijiro Shiomitsu; Reirradiation of Canine Nasal Carcinomas Treated with Coarsely Fractionated Radiation Protocols: 37 Cases. J Am Anim Hosp Assoc 1 September 2013; 49 (5): 318–324. doi: https://doi.org/10.5326/JAAHA-MS-5920
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