Pyrethroids are popular for use in companion animals due to their relatively low mammalian toxicity and efficacy against arthropods. Nonetheless, pyrethroid intoxication has been reported in cats and dogs, and cats appear to be more susceptible due to difficulty in biotransformation and excretion of pyrethroids. Pyrethroid intoxications are generally due to either the improper use or accidental ingestion of approved products. Methocarbamol, given as intermittent injections, is a common first-line treatment choice for the tremors associated with pyrethroid intoxication. Two cats and one dog were treated with a methocarbamol continuous rate infusion (CRI) for pyrethroid intoxication. Clinical signs of toxicity resolved within a few hr in all three cases, with no adverse drug effects. A methocarbamol CRI can be considered in animals presenting with pyrethroid intoxication.
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September/October 2013
Case Reports|
September 01 2013
Methocarbamol CRI for Symptomatic Treatment of Pyrethroid Intoxication: A Report of Three Cases
William E. Draper, DVM;
William E. Draper, DVM
*
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (W.D., T.S.); and Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL (L.B., E.C., M.M).
Correspondence: [email protected] (W.D.)
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Luiz Bolfer, DVM;
Luiz Bolfer, DVM
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (W.D., T.S.); and Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL (L.B., E.C., M.M).
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Emily Cottam, DVM;
Emily Cottam, DVM
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (W.D., T.S.); and Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL (L.B., E.C., M.M).
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Maureen McMichael, DVM;
Maureen McMichael, DVM
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (W.D., T.S.); and Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL (L.B., E.C., M.M).
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Thomas Schubert, DVM
Thomas Schubert, DVM
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (W.D., T.S.); and Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL (L.B., E.C., M.M).
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J Am Anim Hosp Assoc (2013) 49 (5): 325–328.
Citation
William E. Draper, Luiz Bolfer, Emily Cottam, Maureen McMichael, Thomas Schubert; Methocarbamol CRI for Symptomatic Treatment of Pyrethroid Intoxication: A Report of Three Cases. J Am Anim Hosp Assoc 1 September 2013; 49 (5): 325–328. doi: https://doi.org/10.5326/JAAHA-MS-5835
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