Canine B-cell lymphoma is a highly treatable disease, but cost and logistical factors may hamper an owner’s ability to pursue treatment of their pet with this disease. The authors evaluated the use of single-agent doxorubicin in an intermittent fashion for efficacy in the treatment of this disease. Morphologic and clinical data were analyzed for prognostic significance. Eighteen dogs with B-cell lymphoma, all with multicentric disease, were enrolled. The overall complete response (CR) rate was 78%, median total doxorubicin remission time (TDR) was 80.5 days, and median overall survival (OS) was 169.5 days. The median number of doxorubicin doses administered was 4.5. First remission times were significantly affected by clinical stage and substage of disease. Outcome for the dogs in this study were similar to those previously reported for single-agent doxorubicin treatment. Additionally, the intermittent nature of the treatments made the described protocol more feasible for the owners who enrolled their pets in this study. Intermittent single-agent doxorubicin is not a substitute for multiagent chemotherapy protocols in the treatment of canine lymphoma; however, it is a reasonable alternative if the cost and time commitments are limiting factors for an owner.
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November/December 2013
Original Studies|
November 01 2013
Intermittent Single-Agent Doxorubicin for the Treatment of Canine B-Cell Lymphoma
Mary Lynn Higginbotham, MS, DVM, DACVIM;
Mary Lynn Higginbotham, MS, DVM, DACVIM
Department of Clinical Sciences (M.H., D.M., K.R., J.R., D.B.) and Department of Diagnostic Medicine/Pathobiology (J.N., M.W.), College of Veterinary Medicine, Kansas State University, Manhattan, KS; and Boren Veterinary Medical Teaching Hospital, Stillwater, OK (K.R.).
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Dudley L. McCaw, DVM, DACVIM;
Dudley L. McCaw, DVM, DACVIM
Department of Clinical Sciences (M.H., D.M., K.R., J.R., D.B.) and Department of Diagnostic Medicine/Pathobiology (J.N., M.W.), College of Veterinary Medicine, Kansas State University, Manhattan, KS; and Boren Veterinary Medical Teaching Hospital, Stillwater, OK (K.R.).
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James K. Roush, MS, DVM, DACVS;
James K. Roush, MS, DVM, DACVS
Department of Clinical Sciences (M.H., D.M., K.R., J.R., D.B.) and Department of Diagnostic Medicine/Pathobiology (J.N., M.W.), College of Veterinary Medicine, Kansas State University, Manhattan, KS; and Boren Veterinary Medical Teaching Hospital, Stillwater, OK (K.R.).
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Jerome C. Nietfeld, MS, PhD, DVM, DACVP;
Jerome C. Nietfeld, MS, PhD, DVM, DACVP
Department of Clinical Sciences (M.H., D.M., K.R., J.R., D.B.) and Department of Diagnostic Medicine/Pathobiology (J.N., M.W.), College of Veterinary Medicine, Kansas State University, Manhattan, KS; and Boren Veterinary Medical Teaching Hospital, Stillwater, OK (K.R.).
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Melinda J. Wilkerson, MS, PhD, DVM, DACVP;
Melinda J. Wilkerson, MS, PhD, DVM, DACVP
Department of Clinical Sciences (M.H., D.M., K.R., J.R., D.B.) and Department of Diagnostic Medicine/Pathobiology (J.N., M.W.), College of Veterinary Medicine, Kansas State University, Manhattan, KS; and Boren Veterinary Medical Teaching Hospital, Stillwater, OK (K.R.).
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Kimberly Reeds, MS, DVM;
Department of Clinical Sciences (M.H., D.M., K.R., J.R., D.B.) and Department of Diagnostic Medicine/Pathobiology (J.N., M.W.), College of Veterinary Medicine, Kansas State University, Manhattan, KS; and Boren Veterinary Medical Teaching Hospital, Stillwater, OK (K.R.).
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Diana Burr, MS, DVM
Department of Clinical Sciences (M.H., D.M., K.R., J.R., D.B.) and Department of Diagnostic Medicine/Pathobiology (J.N., M.W.), College of Veterinary Medicine, Kansas State University, Manhattan, KS; and Boren Veterinary Medical Teaching Hospital, Stillwater, OK (K.R.).
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J Am Anim Hosp Assoc (2013) 49 (6): 357–362.
Citation
Mary Lynn Higginbotham, Dudley L. McCaw, James K. Roush, Jerome C. Nietfeld, Melinda J. Wilkerson, Kimberly Reeds, Diana Burr; Intermittent Single-Agent Doxorubicin for the Treatment of Canine B-Cell Lymphoma. J Am Anim Hosp Assoc 1 November 2013; 49 (6): 357–362. doi: https://doi.org/10.5326/JAAHA-MS-5929
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