Hemangiosarcomas (HSAs) are aggressive tumors with a high rate of metastasis. Clinical stage has been considered a negative prognostic factor for survival. The study authors hypothesized that the median survival time (MST) of dogs with metastatic (stage III) HSA treated with a vincristine, doxorubicin, and cyclophosphamide (VAC) chemotherapy protocol would not be different than those with stage I/II HSA. Sixty-seven dogs with HSA in different anatomic locations were evaluated retrospectively. All dogs received the VAC protocol as an adjuvant to surgery (n = 50), neoadjuvant (n = 3), or as the sole treatment modality (n = 14). There was no significant difference (P = 0.97) between the MST of dogs with stage III and stage I/II HSA. For dogs presenting with splenic HSA alone, there was no significant difference between the MST of dogs with stage III and stage I/II disease (P = 0.12). The overall response rate (complete response [CR] and partial response [PR]) was 86%). No unacceptable toxicities were observed. Dogs with stage III HSA treated with the VAC protocol have a similar prognosis to dogs with stage I/II HSA. Dogs with HSA and evidence of metastases at the time of diagnosis should not be denied treatment.
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November/December 2013
Retrospective Studies|
November 01 2013
VAC Protocol for Treatment of Dogs with Stage III Hemangiosarcoma
Francisco J. Alvarez, DVM, MS, DACVIM;
Francisco J. Alvarez, DVM, MS, DACVIM
Coral Springs Animal Hospital, Coral Springs, FL (F.A.); Hokkaido University, Graduate School of Veterinary Medicine, Hokkaido, Japan (K.H.); University of London, Royal Veterinary College, London, United Kingdom (A.L-G.); and The Ohio State University, College of Veterinary Medicine, Columbus, OH (W.K., G.C.).
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Kenji Hosoya, DVM, MS, DACVR, DACVIM;
Kenji Hosoya, DVM, MS, DACVR, DACVIM
Coral Springs Animal Hospital, Coral Springs, FL (F.A.); Hokkaido University, Graduate School of Veterinary Medicine, Hokkaido, Japan (K.H.); University of London, Royal Veterinary College, London, United Kingdom (A.L-G.); and The Ohio State University, College of Veterinary Medicine, Columbus, OH (W.K., G.C.).
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Ana Lara-Garcia, DVM, MS, PhD, DACVIM, MRCVS;
Ana Lara-Garcia, DVM, MS, PhD, DACVIM, MRCVS
Coral Springs Animal Hospital, Coral Springs, FL (F.A.); Hokkaido University, Graduate School of Veterinary Medicine, Hokkaido, Japan (K.H.); University of London, Royal Veterinary College, London, United Kingdom (A.L-G.); and The Ohio State University, College of Veterinary Medicine, Columbus, OH (W.K., G.C.).
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William Kisseberth, DVM, MS, PhD, DACVIM;
William Kisseberth, DVM, MS, PhD, DACVIM
Coral Springs Animal Hospital, Coral Springs, FL (F.A.); Hokkaido University, Graduate School of Veterinary Medicine, Hokkaido, Japan (K.H.); University of London, Royal Veterinary College, London, United Kingdom (A.L-G.); and The Ohio State University, College of Veterinary Medicine, Columbus, OH (W.K., G.C.).
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Guillermo Couto, DVM, DACVIM
Guillermo Couto, DVM, DACVIM
Coral Springs Animal Hospital, Coral Springs, FL (F.A.); Hokkaido University, Graduate School of Veterinary Medicine, Hokkaido, Japan (K.H.); University of London, Royal Veterinary College, London, United Kingdom (A.L-G.); and The Ohio State University, College of Veterinary Medicine, Columbus, OH (W.K., G.C.).
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J Am Anim Hosp Assoc (2013) 49 (6): 370–377.
Citation
Francisco J. Alvarez, Kenji Hosoya, Ana Lara-Garcia, William Kisseberth, Guillermo Couto; VAC Protocol for Treatment of Dogs with Stage III Hemangiosarcoma. J Am Anim Hosp Assoc 1 November 2013; 49 (6): 370–377. doi: https://doi.org/10.5326/JAAHA-MS-5954
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