A 10 yr old castrated male Siberian husky was evaluated for polyuria, polydipsia, a retroperitoneal mass, and urolithiasis. A marked elevation in Ca was noted on initial blood work, and results of additional testing were consistent with hypercalcemia of malignancy, including an elevated parathyroid hormone-related peptide (PTHrp) value. Based on clinical signs, blood work, diagnostic imaging, and cytology results, unilateral renal neoplasia was suspected. Following a complete right nephrectomy and cystotomy, histopathologic examination confirmed a diagnosis of renal cell carcinoma (RCC). Five days postoperatively, the hypercalcemia had nearly resolved and the PTHrp was zero. This is the first reported case of hypercalcemia of malignancy associated with RCC in a dog.
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November/December 2013
Case Reports|
November 01 2013
Hypercalcemia of Malignancy Associated with Renal Cell Carcinoma in a Dog
Christine H. Merrick, DVM;
VCA Bay Area Veterinary Specialists, San Leandro, CA (C.H.M.); the Columbia River Veterinary Specialists, Vancouver, WA (C.L.M.); and Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (S.S., A.S., E.G., C.J.).
Correspondence: [email protected] (C.M.)
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Stephanie E. Schleis, DVM, DACVIM (Oncology);
Stephanie E. Schleis, DVM, DACVIM (Oncology)
VCA Bay Area Veterinary Specialists, San Leandro, CA (C.H.M.); the Columbia River Veterinary Specialists, Vancouver, WA (C.L.M.); and Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (S.S., A.S., E.G., C.J.).
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Annette N. Smith, MS, DVM, DACVIM (Oncology and Internal Medicine);
Annette N. Smith, MS, DVM, DACVIM (Oncology and Internal Medicine)
VCA Bay Area Veterinary Specialists, San Leandro, CA (C.H.M.); the Columbia River Veterinary Specialists, Vancouver, WA (C.L.M.); and Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (S.S., A.S., E.G., C.J.).
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Courtney L. Mallett, DVM, DACVIM (Oncology);
Courtney L. Mallett, DVM, DACVIM (Oncology)
VCA Bay Area Veterinary Specialists, San Leandro, CA (C.H.M.); the Columbia River Veterinary Specialists, Vancouver, WA (C.L.M.); and Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (S.S., A.S., E.G., C.J.).
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Emily C. Graff, DVM, DACVP;
Emily C. Graff, DVM, DACVP
VCA Bay Area Veterinary Specialists, San Leandro, CA (C.H.M.); the Columbia River Veterinary Specialists, Vancouver, WA (C.L.M.); and Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (S.S., A.S., E.G., C.J.).
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Calvin Johnson, PhD, DVM, DACVP
Calvin Johnson, PhD, DVM, DACVP
VCA Bay Area Veterinary Specialists, San Leandro, CA (C.H.M.); the Columbia River Veterinary Specialists, Vancouver, WA (C.L.M.); and Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL (S.S., A.S., E.G., C.J.).
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J Am Anim Hosp Assoc (2013) 49 (6): 385–388.
Citation
Christine H. Merrick, Stephanie E. Schleis, Annette N. Smith, Courtney L. Mallett, Emily C. Graff, Calvin Johnson; Hypercalcemia of Malignancy Associated with Renal Cell Carcinoma in a Dog. J Am Anim Hosp Assoc 1 November 2013; 49 (6): 385–388. doi: https://doi.org/10.5326/JAAHA-MS-5895
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