A 7 yr old castrated male Great Dane presented with a history of progressive myelopathy following the intramuscular injection of melarsomine dihydrochloride 8 wk previously. MRI revealed paraspinal and epidural abscesses at the 13th thoracic (T13) and first lumbar (L1) disc space. The dog’s condition worsened despite medical management, necessitating surgical decompression. Surgical decompression resulted in rapid improvement of the patient’s clinical signs. Histopathologic evaluation of the lesions revealed pyogranulomatous inflammation. Cultures of fluid and tissue within the lesions were negative for bacterial growth, and no infectious organisms were visualized histologically. Melarsomine-associated neurologic signs can be chronic and progressive in nature, presumably secondary to ongoing sterile inflammation that may result in spinal cord compression.
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November/December 2013
Case Reports|
November 01 2013
Chronic Compressive Myelopathy and Progressive Neurologic Signs Associated with Melarsomine Dihydrochloride Administration in a Dog
Sarah A. Moore, DVM, DACVIM (Neurology);
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH (S.M.); and Department of Clinical Sciences (C.M.) and Department of Population Health & Pathobiology (A.VW., L.B.), College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Correspondence: [email protected] (S.M.)
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Christopher L. Mariani, DVM, PhD, DACVIM (Neurology);
Christopher L. Mariani, DVM, PhD, DACVIM (Neurology)
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH (S.M.); and Department of Clinical Sciences (C.M.) and Department of Population Health & Pathobiology (A.VW., L.B.), College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
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Arnaud Van Wettere, DVM, MS, PhD, DACVP;
Arnaud Van Wettere, DVM, MS, PhD, DACVP
*
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH (S.M.); and Department of Clinical Sciences (C.M.) and Department of Population Health & Pathobiology (A.VW., L.B.), College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
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Luke B. Borst, DVM, PhD, DACVP
Luke B. Borst, DVM, PhD, DACVP
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH (S.M.); and Department of Clinical Sciences (C.M.) and Department of Population Health & Pathobiology (A.VW., L.B.), College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
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J Am Anim Hosp Assoc (2013) 49 (6): 389–393.
Citation
Sarah A. Moore, Christopher L. Mariani, Arnaud Van Wettere, Luke B. Borst; Chronic Compressive Myelopathy and Progressive Neurologic Signs Associated with Melarsomine Dihydrochloride Administration in a Dog. J Am Anim Hosp Assoc 1 November 2013; 49 (6): 389–393. doi: https://doi.org/10.5326/JAAHA-MS-5911
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