An 8 yr old castrated male Labrador retriever mixed-breed dog with osteosarcoma (OSA) of the left proximal humerus receiving carboplatin presented 10 days after the third chemotherapy treatment with hematuria, stranguria, and pollakiuria. A presumptive diagnosis of hemorrhagic cystitis was made based on clinical signs, urinalysis, and cytologic analysis of a traumatic catheterization sample. Carboplatin was removed from the chemotherapy treatment plan and was substituted with doxorubicin. The dog was treated with meloxicam for pain, and the cystitis signs subsided over a period of 4 wk. Carboplatin is commonly used as adjuvant chemotherapy for dogs with OSA following amputation and is not known to cause hematuria in dogs, although there are reports of this occurring in humans. To the authors’ knowledge, there are no reports in the veterinary literature of this toxicity.
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January/February 2014
Case Reports|
January 01 2014
Hemorrhagic Cystitis in a Dog Receiving Carboplatin
Valerie MacDonald, DVM, DACVIM (Oncology);
Department of Small Animal Clinical Sciences (V.M.) and Prairie Diagnostic Services (R.D.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Correspondence: [email protected] (V.M.)
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Ryan Dickinson, DVM, DACVP
Ryan Dickinson, DVM, DACVP
Department of Small Animal Clinical Sciences (V.M.) and Prairie Diagnostic Services (R.D.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
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J Am Anim Hosp Assoc (2014) 50 (1): 67–70.
Citation
Valerie MacDonald, Ryan Dickinson; Hemorrhagic Cystitis in a Dog Receiving Carboplatin. J Am Anim Hosp Assoc 1 January 2014; 50 (1): 67–70. doi: https://doi.org/10.5326/JAAHA-MS-5965
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