An image-guided robotic stereotactic radiosurgery (SRS) system can be used to deliver curative-intent radiation in either single fraction or hypofractionated doses. Medical records for 19 dogs with nonlymphomatous nasal tumors treated with hypofractionated image-guided robotic stereotactic body radiotherapy (SBRT), either with or without adjunctive treatment, were retrospectively analyzed for survival and prognostic factors. Median survival time (MST) was evaluated using Kaplan-Meier survival curves. Age, breed, tumor type, stage, tumor size, prescribed radiation dose, and heterogeneity index were analyzed for prognostic significance. Dogs were treated with three consecutive-day, 8–12 gray (Gy) fractions of image-guided robotic SBRT. Overall MST was 399 days. No significant prognostic factors were identified. Acute side effects were rare and mild. Late side effects included one dog with an oronasal fistula and six dogs with seizures. In three of six dogs, seizures were a presenting complaint prior to SBRT. The cause of seizures in the remaining three dogs could not be definitively determined due to lack of follow-up computed tomography (CT) imaging. The seizures could have been related to either progression of disease or late radiation effect. Results indicate that image-guided robotic SBRT, either with or without adjunctive therapy, for canine nonlymphomatous nasal tumors provides comparable survival times (STs) to daily fractionated megavoltage radiation with fewer required fractions and fewer acute side effects.
Skip Nav Destination
Article navigation
March/April 2014
Retrospective Studies|
March 01 2014
Use of an Image-Guided Robotic Radiosurgery System for the Treatment of Canine Nonlymphomatous Nasal Tumors
Seth A. Glasser, DVM, DACVIM (Oncology);
Seth A. Glasser, DVM, DACVIM (Oncology)
*
Animal Specialty Center, Yonkers, NY.
Correspondence: [email protected] (S.G.)
Search for other works by this author on:
Sarah Charney, DVM, DACVIM (Oncology), DACVR (Radiation Oncology);
Sarah Charney, DVM, DACVIM (Oncology), DACVR (Radiation Oncology)
Animal Specialty Center, Yonkers, NY.
Search for other works by this author on:
Nikolaos G. Dervisis, DVM, DACVIM (Oncology);
Nikolaos G. Dervisis, DVM, DACVIM (Oncology)
†
Animal Specialty Center, Yonkers, NY.
Search for other works by this author on:
Matthew R. Witten, PhD, DABR (Medical Physics);
Matthew R. Witten, PhD, DABR (Medical Physics)
Animal Specialty Center, Yonkers, NY.
Search for other works by this author on:
Susan Ettinger, DVM, DACVIM (Oncology);
Susan Ettinger, DVM, DACVIM (Oncology)
Animal Specialty Center, Yonkers, NY.
Search for other works by this author on:
Jason Berg, DVM, DACVIM (Internal Medicine and Neurology);
Jason Berg, DVM, DACVIM (Internal Medicine and Neurology)
Animal Specialty Center, Yonkers, NY.
Search for other works by this author on:
Richard Joseph, DVM, DACVIM (Neurology)
Richard Joseph, DVM, DACVIM (Neurology)
Animal Specialty Center, Yonkers, NY.
Search for other works by this author on:
J Am Anim Hosp Assoc (2014) 50 (2): 96–104.
Citation
Seth A. Glasser, Sarah Charney, Nikolaos G. Dervisis, Matthew R. Witten, Susan Ettinger, Jason Berg, Richard Joseph; Use of an Image-Guided Robotic Radiosurgery System for the Treatment of Canine Nonlymphomatous Nasal Tumors. J Am Anim Hosp Assoc 1 March 2014; 50 (2): 96–104. doi: https://doi.org/10.5326/JAAHA-MS-6024
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Long-Term Survival of Primary Intracranial Histiocytic Sarcoma Through Surgical Resection and Low-Dose CCNU
Kyosuke Hidari, DVM, Yuya Nakamoto, DVM, PhD, James K. Chambers, DVM, PhD, Kazuyuki Uchida, DVM, PhD, Isao Mori, DVM, Miwa Nakamoto, DVM
Microfilaria in the Urine of a Dog with Concurrent Urinary Bladder Sarcoma
Nicole Schlette, DVM, Erin Burton, DVM, MS, DACVP, Amber Harris, DVM, DACVIM (Internal Medicine), Kendall Langsten, DVM, DACVP, Erik Olson, DVM, PhD, DACVP, Daniel Heinrich, DVM, DACVP
Chronic Myelomonocytic Leukemia with Central Nervous System Involvement in a Dog
Ilaria Tartari, DVM, Fabio Tocco, DVM, Giorgio Cancedda, DVM, Veronica Angioni, DVM, Marco Podda, DVM, Antonella Gallucci, DVM, PhD, DECVN, EBVS
Treatment Outcomes of Canine Orbital Meningiomas in Seven Cases
Akihiro Uno, DVM, Ryota Iwasaki, DVM, PhD, Takashi Mori, DVM, PhD
Transient Hypoadrenocorticism in a 7-Week-Old Kitten
Alba Planas Vintro, BVM, Linda G. Martin, DVM, MS, DACVECC, Cassidy L. Cordon, DVM, Sabrina N. Hoehne, Dr. med. vet., DACVECC, DECVECC, Elizabeth B. Davidow, DVM, DACVECC