A 13 yr old castrated male vizsla was referred to the authors’ institute because of polyuria, polydipsia, polyphagia, and weight loss. Pituitary-dependent hypercortisolism (PDH) was diagnosed by hormone testing and adrenal and pituitary imaging. Computed tomography (CT) revealed a pituitary mass measuring 21 mm in width. Medical therapy was initiated with trilostane. Despite adequate control of the hypercortisolemia, the polyuria and polydipsia persisted and the dog developed neurologic signs due to the pituitary mass effect. Pituitary transsphenoidal debulking surgery was performed and immunocytochemistry confirmed a corticotroph adenoma. The dog survived for 13 mo after surgery. Postmortem examination revealed an empty fossa without pituitary remnants and the presence of a malignant pheochromocytoma in the right adrenal gland. This case report demonstrates, for the first time, that a large pituitary adenoma in the dog may be treated successfully by pituitary surgery.
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May/June 2014
Case Reports|
May 01 2014
Complete Surgical Removal of a Very Enlarged Pituitary Corticotroph Adenoma in a Dog
Federico Fracassi, PhD, DVM, DECVIM-CA;
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy (F.F., L.M., D.S., A.D.); and Department of Pathobiology, Faculty of Veterinary Medicine (G.G.) and Department of Clinical Sciences of Companion Animals (B.M.), Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Correspondence: [email protected] (F.F.)
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Luciana Mandrioli, PhD, DVM;
Luciana Mandrioli, PhD, DVM
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy (F.F., L.M., D.S., A.D.); and Department of Pathobiology, Faculty of Veterinary Medicine (G.G.) and Department of Clinical Sciences of Companion Animals (B.M.), Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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Dardan Shehdula, PhD, DVM;
Dardan Shehdula, PhD, DVM
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy (F.F., L.M., D.S., A.D.); and Department of Pathobiology, Faculty of Veterinary Medicine (G.G.) and Department of Clinical Sciences of Companion Animals (B.M.), Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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Alessia Diana, PhD, DVM;
Alessia Diana, PhD, DVM
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy (F.F., L.M., D.S., A.D.); and Department of Pathobiology, Faculty of Veterinary Medicine (G.G.) and Department of Clinical Sciences of Companion Animals (B.M.), Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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Guy C.M. Grinwis, PhD, DVM;
Guy C.M. Grinwis, PhD, DVM
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy (F.F., L.M., D.S., A.D.); and Department of Pathobiology, Faculty of Veterinary Medicine (G.G.) and Department of Clinical Sciences of Companion Animals (B.M.), Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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Björn P. Meij, PhD, DVM, DECVS
Björn P. Meij, PhD, DVM, DECVS
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy (F.F., L.M., D.S., A.D.); and Department of Pathobiology, Faculty of Veterinary Medicine (G.G.) and Department of Clinical Sciences of Companion Animals (B.M.), Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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J Am Anim Hosp Assoc (2014) 50 (3): 192–197.
Citation
Federico Fracassi, Luciana Mandrioli, Dardan Shehdula, Alessia Diana, Guy C.M. Grinwis, Björn P. Meij; Complete Surgical Removal of a Very Enlarged Pituitary Corticotroph Adenoma in a Dog. J Am Anim Hosp Assoc 1 May 2014; 50 (3): 192–197. doi: https://doi.org/10.5326/JAAHA-MS-5987
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