Cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) is a locally restricted multinodular dermatitis. Affected dogs are typically healthy, but a few show systemic signs. Herein, a case of a dog presenting with generalized ulcerative dermatitis with systemic signs of mild anemia and an increased C-reactive protein level is described. Cutaneous SPGS was diagnosed by histopathology, negative staining causative organisms, and polymerase chain reaction for Mycobacterium spp. Successful treatment was achieved by immunosuppressive drugs, including prednisolone and azathioprine, administered for at least 20 mo. Recurrences of skin lesions were observed when prednisolone and/or azathioprine were discontinued. Long-term management with immunosuppressive agents may be required if the affected dog exhibits severe symptoms of cutaneous SPGS.
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July/August 2014
Case Reports|
August 01 2014
A Case of Cutaneous Sterile Pyogranuloma/Granuloma Syndrome in a Maltese
Shinpei Kawarai, PhD, DVM;
Veterinary Teaching Hospital Laboratory of Small Animal Clinics (S.K., N.K., H.M.), Department of Veterinary Medicine Laboratory of Veterinary Pathology (K.S.), and Laboratory of Microbiology I (A.K.), Azabu University, Sagamihara, Kanagawa, Japan; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (S.M.); and Central Laboratory, Japan BCG Laboratory, Kiyose, Tokyo, Japan (S.Y.).
Correspondence: [email protected] (S.K.)
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Shinobu Matsuura, PhD, DVM;
Shinobu Matsuura, PhD, DVM
Veterinary Teaching Hospital Laboratory of Small Animal Clinics (S.K., N.K., H.M.), Department of Veterinary Medicine Laboratory of Veterinary Pathology (K.S.), and Laboratory of Microbiology I (A.K.), Azabu University, Sagamihara, Kanagawa, Japan; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (S.M.); and Central Laboratory, Japan BCG Laboratory, Kiyose, Tokyo, Japan (S.Y.).
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Saburo Yamamoto, PhD;
Saburo Yamamoto, PhD
Veterinary Teaching Hospital Laboratory of Small Animal Clinics (S.K., N.K., H.M.), Department of Veterinary Medicine Laboratory of Veterinary Pathology (K.S.), and Laboratory of Microbiology I (A.K.), Azabu University, Sagamihara, Kanagawa, Japan; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (S.M.); and Central Laboratory, Japan BCG Laboratory, Kiyose, Tokyo, Japan (S.Y.).
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Akio Kiuchi, PhD, DVM;
Akio Kiuchi, PhD, DVM
Veterinary Teaching Hospital Laboratory of Small Animal Clinics (S.K., N.K., H.M.), Department of Veterinary Medicine Laboratory of Veterinary Pathology (K.S.), and Laboratory of Microbiology I (A.K.), Azabu University, Sagamihara, Kanagawa, Japan; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (S.M.); and Central Laboratory, Japan BCG Laboratory, Kiyose, Tokyo, Japan (S.Y.).
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Nobuyuki Kanemaki, PhD, DVM, DAiCVO;
Nobuyuki Kanemaki, PhD, DVM, DAiCVO
Veterinary Teaching Hospital Laboratory of Small Animal Clinics (S.K., N.K., H.M.), Department of Veterinary Medicine Laboratory of Veterinary Pathology (K.S.), and Laboratory of Microbiology I (A.K.), Azabu University, Sagamihara, Kanagawa, Japan; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (S.M.); and Central Laboratory, Japan BCG Laboratory, Kiyose, Tokyo, Japan (S.Y.).
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Hiroo Madarame, PhD, DVM, DJCVP;
Hiroo Madarame, PhD, DVM, DJCVP
Veterinary Teaching Hospital Laboratory of Small Animal Clinics (S.K., N.K., H.M.), Department of Veterinary Medicine Laboratory of Veterinary Pathology (K.S.), and Laboratory of Microbiology I (A.K.), Azabu University, Sagamihara, Kanagawa, Japan; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (S.M.); and Central Laboratory, Japan BCG Laboratory, Kiyose, Tokyo, Japan (S.Y.).
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Kinji Shirota, PhD, DVM, DJCVP
Kinji Shirota, PhD, DVM, DJCVP
Veterinary Teaching Hospital Laboratory of Small Animal Clinics (S.K., N.K., H.M.), Department of Veterinary Medicine Laboratory of Veterinary Pathology (K.S.), and Laboratory of Microbiology I (A.K.), Azabu University, Sagamihara, Kanagawa, Japan; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (S.M.); and Central Laboratory, Japan BCG Laboratory, Kiyose, Tokyo, Japan (S.Y.).
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J Am Anim Hosp Assoc (2014) 50 (4): 278–283.
Citation
Shinpei Kawarai, Shinobu Matsuura, Saburo Yamamoto, Akio Kiuchi, Nobuyuki Kanemaki, Hiroo Madarame, Kinji Shirota; A Case of Cutaneous Sterile Pyogranuloma/Granuloma Syndrome in a Maltese. J Am Anim Hosp Assoc 1 July 2014; 50 (4): 278–283. doi: https://doi.org/10.5326/JAAHA-MS-6009
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