A 3 yr old wirehaired fox terrier was presented to his primary care veterinarian with fever, thrombocytopenia, and generalized crusting dermatitis. The skin lesion had progressed for at least 18 days, and thrombocytopenia had developed 3 days before presentation. Histopathology and direct immunofluorescence studies of the skin were consistent with pemphigus foliaceus (PF). Immunofluorescence revealed immunoglobulin G deposition around the keratinocytes in the stratum spinosum. A diagnosis of immune-mediated thrombocytopenia (IMT) was confirmed by the presence of platelet surface-associated immunoglobulin using flow cytometry. Systemic immunosuppressive therapy with cyclosporine and azathioprine was effective, and the dog survived for >2 years from the initial presentation. IMT is rarely associated with PF. This appears to be the first detailed report of a definitive diagnosis of concurrent PF and IMT in a dog. The authors' findings indicate that canine PF could be complicated by hematologic immune-mediated diseases such as IMT.
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January/February 2015
Case Reports|
January 01 2015
Canine Pemphigus Foliaceus with Concurrent Immune-Mediated Thrombocytopenia
Shinpei Kawarai, PhD, DVM;
Shinpei Kawarai, PhD, DVM
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Masaharu Hisasue, PhD, DVM;
Masaharu Hisasue, PhD, DVM
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Shinobu Matsuura, PhD, DVM;
Shinobu Matsuura, PhD, DVM
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Tetsuro Ito, DVM;
Tetsuro Ito, DVM
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Yukari Inoue, DVM;
Yukari Inoue, DVM
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Sakurako Neo, PhD, DVM, DACVP;
Sakurako Neo, PhD, DVM, DACVP
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Yoko Fujii, PhD, DVM, DACVIM (Cardiology);
Yoko Fujii, PhD, DVM, DACVIM (Cardiology)
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Hiroo Madarame, PhD, DVM, DJCVP;
Hiroo Madarame, PhD, DVM, DJCVP
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Kinji Shirota, PhD, DVM, DJCVP;
Kinji Shirota, PhD, DVM, DJCVP
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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Ryo Tsuchiya, PhD, DVM
Ryo Tsuchiya, PhD, DVM
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
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J Am Anim Hosp Assoc (2015) 51 (1): 56–63.
Citation
Shinpei Kawarai, Masaharu Hisasue, Shinobu Matsuura, Tetsuro Ito, Yukari Inoue, Sakurako Neo, Yoko Fujii, Hiroo Madarame, Kinji Shirota, Ryo Tsuchiya; Canine Pemphigus Foliaceus with Concurrent Immune-Mediated Thrombocytopenia. J Am Anim Hosp Assoc 1 January 2015; 51 (1): 56–63. doi: https://doi.org/10.5326/JAAHA-MS-6044
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