The quality of life for dogs with osteoarthritis can often be improved with nonsteroidal anti-inflammatory drugs (NSAIDs); however, the number of adverse drug events associated with NSAID use reported to the Federal Drug Administration Center for Veterinary Medicine is higher than that for any other companion animal drug. Of those events, adverse renal reactions are the second most reported. NSAIDs produce pharmacologic effects via inhibition of cyclooxygenase (COX), which decreases production of prostanoids. Prostaglandins are synthesized by both the COX-1 and COX-2 enzymes in the healthy kidney and influence renal blood flow, glomerular filtration rate, renin release, and Na excretion. There are important species differences in the renal expression of COX-1 and COX-2. For example, dogs have higher basal levels of COX-2 expression in the kidney compared with humans. In addition, in dogs with chronic kidney disease, an increase in COX-2 expression occurs and synthesis of prostaglandins shifts to the COX-2 pathway. For those reasons, NSAIDs that target COX-2 may be expected to adversely affect renal function in dogs, especially dogs with chronic kidney disease. The purpose of this review was to evaluate the literature to report the renal effects of NSAIDs in dogs.
Skip Nav Destination
Article navigation
May/June 2015
other|
May 01 2015
The Renal Effects of NSAIDs in Dogs
Amy L. Lomas, DVM, MS, DACVIM;
Amy L. Lomas, DVM, MS, DACVIM
From the Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS.
Search for other works by this author on:
Gregory F. Grauer, DVM, MS, DACVIM
Gregory F. Grauer, DVM, MS, DACVIM
From the Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS.
Search for other works by this author on:
J Am Anim Hosp Assoc (2015) 51 (3): 197–203.
Citation
Amy L. Lomas, Gregory F. Grauer; The Renal Effects of NSAIDs in Dogs. J Am Anim Hosp Assoc 1 May 2015; 51 (3): 197–203. doi: https://doi.org/10.5326/JAAHA-MS-6239
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Evaluation of Intrathecal Injection of Modified Live Newcastle Disease Virus Vaccine in Dogs with Canine Distemper Encephalitis
Kenneth R. Harkin, DVM, DACVIM, Anushka George Karote, MS
Assessment of Adrenal Computed Tomography Characteristics in Cats with Nonadrenal Disease
Stefanie Gaisbauer, DVM, Florian Karl Zeugswetter, Priv. Doz., DVM, Alexander Tichy, Mag. phil., Dr. rer. nat., Conor Rowan, MVB, DVMS, DECVDI, MRCVS, Eberhard Ludewig, DMV habil., DECVDI
Prolonged Survival Following Treatment of Histiocytic Sarcoma of the Canine Urinary Bladder
Steve Patten, DVM, MSc, DACVIM (Oncology), Shawn MacKenzie, DVM, DVSc, DACVR
Anicteric Gallbladder Rupture with Elevated Bile Acids in Abdominal Effusion in a Dog with Cholecystitis
Mireia Pascual, DVM, Emilie Fauchon, DECVDI, Paola Monti, DACVP, Ferran Valls, DECVIM
Cholesterol Granuloma of the Cranial Mediastinum in a Dog
Anastacia Marie Davis, DVM, MS, DACVS, Kevin Lahmers, DVM, PhD, DACVP, Brie Trusiano, DVM, Kurt Zimmerman, DVM, PhD, DACVP, Jake Romeiser, DVM, Joanne Tuohy, DVM, PhD