GM2 gangliosidosis variant 0 (Sandhoff disease, SD) is a fatal, progressive, neurodegenerative lysosomal storage disease caused by simultaneous deficiencies of acid β-hexosaminidases A and B. Canine SD has so far been identified only in two purebreeds. In this article, we present the case of a 10 mo old, male dog of mixed breed that developed progressive neurological signs including ataxia, postural deficit, and visual deficits and finally died at the age of 21 mo. The dog was diagnosed with SD on the basis of the results of biochemical and histopathological analyses. This is the third report of canine SD and the first time it has been identified in a mixed breed.
GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog
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Moeko Kohyama, Akira Yabuki, Yasuaki Kawasaki, Hiroaki Kawaguchi, Naoki Miura, Yoshiaki Kitano, Toshinori Onitsuka, Mohammad Mahbubur Rahman, Noriaki Miyoshi, Osamu Yamato; GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog. J Am Anim Hosp Assoc 1 November 2015; 51 (6): 396–400. doi: https://doi.org/10.5326/JAAHA-MS-6258
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