Glucosamine (GS) is commonly administered as a nutritional supplement to support joint function. Although many supplements are available, the effect of formulation on oral absorption in dogs is unknown. The purpose of this study was to determine the relative bioavailability of GS for liquid, chewable, and tablet formulations containing GS sulfate or hydrochloride and chondroitin sulfate. In a randomized cross-over design, supplements were administered daily for 8 days with a 1 wk washout period between treatments. Liquid or Tablet A was administered to four dogs, whereas Liquid or Tablet B was administered to four additional dogs. When nutraceutical exposure was normalized to the administered dose of GS free base, similar relative bioavailabilities were determined for all three formulations. However, the dose-normalized maximum plasma GS concentration was higher for the liquid supplement (5.5 ± 0.5 μg/mL) than for the two tablets (3.1 ± 0.6 and 2.1 ± 0.6 μg/mL, P < 0.001). Similarly, the time at which maximal plasma GS concentrations occurred was shorter for the liquid formulation (0.7 ± 0.5 hr) than for the two tablets (4.2 ± 0.6 and 5.0 ± 0.6 hr, P < 0.001). These data show that the formulation of joint supplements affects the oral absorption of GS in dogs.
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March/April 2016
Original Studies|
March 01 2016
Comparison of Glucosamine Absorption After Administration of Oral Liquid, Chewable, and Tablet Formulations to Dogs
Lara K. Maxwell, DACVCP;
Lara K. Maxwell, DACVCP
From Oklahoma State University, Stillwater, OK.
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Penny Regier, DVM;
Penny Regier, DVM
From Oklahoma State University, Stillwater, OK.
*P. Regier's present affiliation is Colorado State University, Fort Collins, CO.
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Satyanarayana Achanta, BVSc, PhD
Satyanarayana Achanta, BVSc, PhD
From Oklahoma State University, Stillwater, OK.
†S. Achanta's present affiliation is Duke University School of Medicine, Durham, NC.
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J Am Anim Hosp Assoc (2016) 52 (2): 90–94.
Citation
Lara K. Maxwell, Penny Regier, Satyanarayana Achanta; Comparison of Glucosamine Absorption After Administration of Oral Liquid, Chewable, and Tablet Formulations to Dogs. J Am Anim Hosp Assoc 1 March 2016; 52 (2): 90–94. doi: https://doi.org/10.5326/JAAHA-MS-6267
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