In this study, we present the management of an intra-articular fracture in a 13-year-old boy with WAGR Syndrome, an extremely rare genetic disorder. The goal of this study is to provide possible solutions to the complex pain management requirements presenting in the setting of trauma to the right lower extremity. Given the scarcity of literature available with regard to this condition, we not only aim to increase awareness of the disease, but provide insight into trauma management and expected outcomes.

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