Central venous catheters (CVCs) have become a mainstay and much-needed technology in providing care to patients; for oncology patients, CVCs are indispensable. Although there are clear advantages in using CVCs, complications sometimes occur. One of the most significant and most common complications is catheter-related bloodstream injection (CRBSI). Over the years, many interventions have been developed and found to decrease CRBSI. One such intervention is described in a recent research study that focused on long-term silicone catheters impregnated with minocycline and rifampin. This article discusses this study and its results.