• TA for stabilization and securement of PICCs reduced catheter migration.

  • This solution to catheter migration was safe, inexpensive, and highly effective.

  • TA reduced migration rates from 19.35% to 1.4% in more than 411 inpatients.

  • There was no evidence of phlebitis, cellulitis, or microbial contamination.

  • There also was no evidence of central line infections.


Background: With the advent and popularity of peripherally inserted central catheter (PICC) use, reflected in clinical benefits, growing evidence suggests a possibility for significant consequences due to unsatisfactory securement. Such consequences may be avoided if stabilization has been optimal. Novel securement devices have shown effectiveness; however, each device has had its challenges. With the recognized need to endorse an agent aimed at reducing migration, would the use of a tissue adhesive (TA) be a pioneering alternative to securement?

Methods: A quantitative, causal comparative, descriptive design was proposed to evaluate the relationship between TA applied at the insertion site and the exposed visible catheter length (EVL), with the intent to determine migration. Two groups were compared, 1 group having received the intervention. Analysis of data quantified the efficacy of the intervention.

Results: A 2-sample t-test and χ2 test were used to analyze the variables. Statistical analyses were applied to equate baseline to innovation, encapsulated the solution, and offered a qualitative narrative, presenting a decrease in catheter migrations from 19.35% to 0%; P = 0.010 (FE 0.02), which was statistically significant. No adverse events or central line bloodstream infections were documented in those receiving TA.

Conclusions: This study reports TA as a safe, inexpensive, and highly effective alternative to secure and stabilize PICCs. The continuation of the study for an additional 10 months yielded a 1.4% migration rate in more than 411 participants (P = 0.02), which speaks to the continued use and the sustainability of TA for securement and stabilization of PICCs.

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