Despite the increasing popularity of midline catheters, data on the use of alteplase for restoring midline catheter patency is scarce.


This study aimed to evaluate off-label use of alteplase for midline catheter occlusions. Method: Adults who received alteplase into a midline catheter between January 2015 and May 2018 within a multi-hospital health system were included in this study. The primary outcome was restoration of infusion or withdrawal function from at least one lumen of a treated midline catheter.


Following alteplase administration, withdrawal function was restored in 47% (25/53) of occlusion events, infusion function was restored in 65% (11/17) of complete occlusion events, and infusion or withdrawal function was restored in 58% (31/53) of occlusion events. Only 34% (17/50) of catheters were replaced because of malfunction. Local bleeding was documented in 9% (n=5) of occlusion events after alteplase administration.


Most midline catheter occlusions treated with alteplase demonstrated restoration of infusion or withdrawal function.

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