Infusion Therapy and vascular access devices have had a profound impact on nursing practice over the years. The domain of nursing practice lends itself to providing an open window of opportunity for the nurse to enter different arenas of nursing practice and to develop expertise in a chosen field. That is what happened at the M.D. Anderson Cancer Center, Houston, TX, in the 1970s. This article provides an overview of the history of the Infusion Therapy Team along with current and future practice.