Although case management is now well established within many areas of healthcare, its use in home infusion remains sporadic and largely undocumented. Few published examples exist in the literature. At the same time, home care professionals remain under intense pressure to provide high quality and often technically complex care in a cost-effective manner. Case management has been proposed as a method for achieving this goal in home infusion. This, article describes two current models, acute and chronic, of case management. They are discussed in terms of the Case Management Society of America's basic program definition and present how adaptations of the basic definition function to meet the specific patient needs in home infusion.