As the global death toll from the novel coronavirus disease 2019 (COVID-19) rises above 1.5 million, with more than 300,000 deaths in the US compared to 1,000 in Australia (1), health professionals must consider all interventions that have potential to reduce infection rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and morbidity and mortality associated with COVID-19. Exercise is a potent immune system stimulus (2) that mitigates many health risk factors associated with COVID-19 hospitalization. In this article we review how exercise enhances immune system function, discuss conditions and diseases associated with COVID-19 mitigated by exercise, and provide exercise prescription information for primary and secondary prevention of SARS-CoV-2 infection.

The immune system includes many types of cells that work together to locate and destroy viruses, as illustrated in Figure 1. These include lymphocytes, neutrophils, and macrophages....

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