Patient X is a 44-year-old white woman diagnosed in November 2020 with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel β-coronavirus, which causes coronavirus disease 2019 (COVID-19) (Table 1) (1). Her symptoms persisted for >6 months postinfection leading to a diagnosis of long-COVID (2). Prior to testing positive for COVID-19 she had been participating in ≤2 hours of moderate to vigorous intensity treadmill, over-ground, and ergometer-based exercise 5 to 6 days per week. She did not perform resistance training. Her medical history and progression from COVID-19 to long-COVID are illustrated in Figures 1 and 2, respectively.

Shortly after becoming infected with COVID-19, and continuing for the ensuing 2 weeks, she self-administered over-the-counter medications, including 600 mg of guaifenesin twice daily, 500 mg of acetaminophen 4 times daily, and cough drops. Despite these therapies, she continued to experience symptoms of dyspnea and fatigue,...

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