Blaess J, Goepfert T, Geneton S, Irenee E, Gerard H, Taesch F, Sordet C, Arnaud L. Benefits & risks of physical activity in patients with systemic lupus erythematosus: a systematic review of the literature. Semin Arthritis Rheum. 2023 Feb;58:152128. Epub 2022 Nov 19. doi:10.1016/j.semarthrit.2022.152128. PMID: 36436314
There has been little clinical exercise physiology research performed on individuals with systemic lupus erythematosus (SLE). Significant and severe fatigue is the primary symptom reported. Those with SLE are at increased risk of cardiovascular disease and metabolic syndrome because of progression of the disease and glucocorticoid treatment. Compared to healthy individuals, those with SLE exhibit higher brachial and carotid systolic blood pressure. Inactivity results in higher levels of inflammatory markers such as CRP, IL-2, and TNF-α. Due to the nature of SLE, inactivity is common, which further promotes a decline in health. Recent trials have evaluated the impact of physical activity (PA) on patients...