Objective: To determine the association between the ApaI, FokI, Cdx2 and TaqI polymorphisms of vitamin D receptor (VDR) gene in caries-active (high-moderate) and caries-free children. Study design: A hundred and fifty children (75 males, 75 females, mean age: 10.19 ± 1.61 years) were included in the study. The subjects were divided into three groups as high caries risk group (DMFT, dft>4)(n=55), moderate caries risk group (DMFT, dft=1–4)(n=57) and caries-free group (n=38). From each individual, blood samples were collected and DNA was extracted. The VDR gene was genotyped for the polymorphisms ApaI, FokI, Cdx2 and TaqI using polymerase chain reaction and restriction fragment length polymorphism methods. All data were analyzed by chi-square test, Fisher's exact test and t test. Results: There was statistically significant difference in the frequency of TaqI genotypes (tt) between caries-active and caries-free children (p=0.029). No statistically significant differences were detected between ApaI, FokI, Cdx2 genotypes and dental caries. Conclusion: In the future, VDR gene polymorphisms may be used as a marker for the identification of patients with high caries risk.
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1 June 2016
Research Article|
June 01 2016
The Role of Vitamin D Receptor Polymorphisms on Dental Caries
Dilsah Cogulu;
Dilsah Cogulu
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Send all correspondence to Dilsah Cogulu, Ege University School of Dentistry, Department of Pedodontics, 35100 Bornova-Izmir, TURKEY, Phone: +90 232 3886431, Fax: +90 232 3880325, E-mail: dilsah.cogulu@ege.edu.tr
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J Clin Pediatr Dent (2016) 40 (3): 211–214.
Citation
Dilsah Cogulu, Huseyin Onay, Yasemin Ozdemir, Gulcin Itirli Aslan, Ferda Ozkinay, Cemal Eronat; The Role of Vitamin D Receptor Polymorphisms on Dental Caries. J Clin Pediatr Dent 1 June 2016; 40 (3): 211–214. doi: https://doi.org/10.17796/1053-4628-40.3.211
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