Fluoride, one of the most celebrated ingredients for the prevention of dental caries in the 20th century, has also been controversial for its use in dentifrices and other applications. In the current review, we have concentrated primarily on early-life exposure to fluoride and how it may affect the various organs. The most recent controversial aspects of fluoride are related to toxicity of the developing brain and how it may possibly result in the decrease of intelligence quotient (IQ), autism, and calcification of the pineal gland. In addition, it has been reported to have possible effects on bone and thyroid glands. If nutritional stress is applied during a critical period of growth and development, the organ(s) and/or body will never recover once they pass through the critical period. For example, if animals are force-fed during experiments, they will simply get fat but never reach the normal size. Although early-life fluoride exposure causing fluorosis is well reported in the literature, the dental profession considers it primarily as an esthetic rather than a serious systemic problem. In the current review, we wanted to raise the possibility of future disease as a result of early-life exposure to fluoride. It is not currently known how fluoride will become a cause of future disease. Studies of other nutritional factors have shown that the effects of early nutritional stress are a cause of disease in later life.
Skip Nav Destination
Article navigation
1 August 2018
Research Article|
January 01 2018
Fluoride Exposure in Early Life as the Possible Root Cause of Disease In Later Life
Tetsuo Nakamoto;
Tetsuo Nakamoto
*
Send the correspondence to: Tetsuo Nakamoto, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, Louisiana 70112. Phone: 504-467-4887, E-mail: tnakam@lsuhsc.edu
Search for other works by this author on:
J Clin Pediatr Dent (2018) 42 (5): 325–330.
Citation
Tetsuo Nakamoto, H Ralph Rawls; Fluoride Exposure in Early Life as the Possible Root Cause of Disease In Later Life. J Clin Pediatr Dent 1 August 2018; 42 (5): 325–330. doi: https://doi.org/10.17796/1053-4625-42.5.1
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Salivary IL-4: A Bleeding Predictor on Probing in Descendants of Severe Periodontitis Patients
Mabelle Freitas Monteiro, Hélvis Enri de Sousa Paz, Larissa Bizarre, Gabriela Martin Bonilha, Marcio Zaffalon Casati, Renato Corrêa Viana Casarin
Newer Technique of Extra-Coronal Bleaching with Sodium Perborate on Non-Pitted Fluorosis Stains in Permanent Anterior Teeth
Ruchi Singhal, Ritu Namdev, Parul Singhal, Nisha Rajput, Saurabh Narang
Dentinogenic Ghost Cell Tumor associated with Odontoma: A unique Histopathological Entity and its Surgical Management
Aadithya B Urs, Kiran Jot, R Maheswari, Arpit Gupta, Sujata Mohanty
Relationship Between Dental Caries and YKL-40 Levels in Saliva
Gulsum Duruk, Esra Laloglu