Delayed tooth development (DTD) is the development progress of a tooth germ that takes place later due to local or general causes. This case report reviews a 16-year-old Asian adolescent whose bilateral upper second premolar germs were at Nolla’s 6 stage as shown on a panoramic radiograph. It is unusual that tooth germs of the maxillary second premolar are developed after 11 years of age. To reduce the chance of misdiagnosis, clinicians should consider the possibility of DTD if a tooth germ does not present in radiographs.