Lactobacillus acidophilus exerted antagonistic actions on growth of Staphylococcus aureus, Salmonella typhimurium, enteropathogenic Escherichia coli, and Clostridium perfringens when grown with each in associative cultures. S. aureus and C. perfringens were more sensitive to the inhibition than were S. typhimurium and E. coli. The amount of the antagonism produced varied among strains of L. acidophilus and could not be directly related to amounts of acid produced; hydrogen peroxide produced by the lactobacilli appeared to be partially responsible for the antagonistic interaction. The inhibitory effect was produced also under anaerobic conditions in a pre-reduced medium.

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Author notes

1Paper number 5155 of the Journal Series of the North Carolina Agricultural Experiment Station, Raleigh, North Carolina. The use of trade names in this publication does not imply endorsement by the North Carolina Agricultural Experiment Station of the products named nor criticism of similar ones not mentioned.

2Present address: Department of Animal Science and Industry, Oklahoma State University, Stillwater, Oklahoma 74074.